9Y60
Crystal structure of NSD2 PWWP1 domain in complex with (6R)-6-(3,5-dichlorophenyl)morpholin-3-one (ligand 2)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Histone-lysine N-methyltransferase NSD2 | polymer | 174 | 19760.6 | 1 | UniProt (O96028) | Homo sapiens (human) | Multiple myeloma SET domain-containing protein,MMSET,Nuclear SET domain-containing protein 2,Protein trithorax-5,Wolf-Hirschhorn syndrome candidate 1 protein |
| 2 | B (A) | (6R)-6-(3,5-dichlorophenyl)morpholin-3-one | non-polymer | 246.1 | 1 | Chemie (A1CSP) | |||
| 3 | C (A) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
A: 202 - 368 (UniProt: O96028)
| PDB | External Database | Details |
|---|---|---|
| Met 201 | - | initiating methionine |
| Ala 361 | Lys 361 | conflict |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
| His 373 | - | expression tag |
| His 374 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19760.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 246.1 | |
| All* | Total formula weight | 20006.7 |
