9Y5R

Eukaryotic translation initiation factor 2-B (eIF2B) bound to phosphorylated eIF2alpha (NTD)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (A, B)	Translation initiation factor eIF-2B subunit epsilon	polymer	721	80452.6	2	UniProt (Q13144)	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit epsilon
2	B, G (C, D)	Translation initiation factor eIF-2B subunit beta	polymer	368	41008.6	2	UniProt (P49770)	Homo sapiens (human)	S20I15,S20III15,eIF-2B GDP-GTP exchange factor subunit beta
3	C, H (E, F)	Translation initiation factor eIF-2B subunit delta	polymer	523	57640.2	2	UniProt (Q9UI10)	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit delta
4	D, I (G, H)	Translation initiation factor eIF-2B subunit alpha	polymer	305	33754.1	2	UniProt (Q14232)	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit alpha
5	E, J (I, J)	Translation initiation factor eIF-2B subunit gamma	polymer	452	50304.2	2	UniProt (Q9NR50)	Homo sapiens (human)	eIF-2B GDP-GTP exchange factor subunit gamma
6	K, L (L, M)	Eukaryotic translation initiation factor 2 subunit 1	polymer	222	25647.1	2	UniProt (P05198)	Homo sapiens (human)	Eukaryotic translation initiation factor 2 subunit alpha,eIF-2-alpha,eIF-2A,eIF-2alpha,eIF2-alpha
7	M, O (E, F)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL) PubChem (312)
8	N, P (E, F)	ZINC ION	non-polymer		65.4	2	Chemie (ZN) PubChem (32051)

Sequence modifications

A, B: 1 - 721 (UniProt: Q13144)

PDB	External Database	Details
Val 587	Ile 587	conflict

C, D: 2 - 351 (UniProt: P49770)

PDB	External Database	Details
Met -16	-	initiating methionine
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Gly -9	-	expression tag
Gly -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
Glu -5	-	expression tag
Asn -4	-	expression tag
Leu -3	-	expression tag
Tyr -2	-	expression tag
Phe -1	-	expression tag
Gln 0	-	expression tag
Ser 1	-	expression tag

L, M: 2 - 187 (UniProt: P05198)

PDB	External Database	Details
Met -34	-	initiating methionine
Gly -33	-	expression tag
Ser -32	-	expression tag
Ser -31	-	expression tag
His -30	-	expression tag
His -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
Ser -24	-	expression tag
Ser -23	-	expression tag
Gly -22	-	expression tag
Leu -21	-	expression tag
Val -20	-	expression tag
Pro -19	-	expression tag
Arg -18	-	expression tag
Gly -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
Met -14	-	expression tag
Ala -13	-	expression tag
Ser -12	-	expression tag
Met -11	-	expression tag
Thr -10	-	expression tag
Gly -9	-	expression tag
Gly -8	-	expression tag
Gln -7	-	expression tag
Gln -6	-	expression tag
Met -5	-	expression tag
Gly -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
Glu 0	-	expression tag
Phe 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	577613.6
Non-Polymers*	Number of molecules	4
	Total formula weight	201.7
All*	Total formula weight	577815.4

*Water molecules are not included.