9Y1X
Crystal structure of NRas-G12D in complex with GDP and IACS-56676
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | GTPase NRas | polymer | 171 | 19410.9 | 2 | UniProt (P01111) Pfam (PF00071) | Homo sapiens (human) | Transforming protein N-Ras |
| 2 | C, G (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) PubChem (136073927) | |||
| 3 | D, H (A, B) | N-({(6P)-6-[5-amino-3-chloro-2-(trifluoromethyl)phenyl]-3-[(1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6-yl]-1,4-dicyclopropyl-7-fluoro-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)acetamide | non-polymer | 562.0 | 2 | Chemie (A1CRW) | |||
| 4 | E, I, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) | |||
| 5 | F (B) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) PubChem (311) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 169 (UniProt: P01111)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38821.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2275.4 | |
| All* | Total formula weight | 41097.3 |
