9Y1X
Crystal structure of NRas-G12D in complex with GDP and IACS-56676
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | GTPase NRas | polymer | 171 | 19410.9 | 2 | UniProt (P01111) Pfam (PF00071) | Homo sapiens (human) | Transforming protein N-Ras |
| 2 | C, G (A, B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 3 | D, H (A, B) | N-({(6P)-6-[5-amino-3-chloro-2-(trifluoromethyl)phenyl]-3-[(1R,5S,6s)-3-azabicyclo[3.1.0]hexan-6-yl]-1,4-dicyclopropyl-7-fluoro-1H-pyrrolo[3,2-c]pyridin-2-yl}methyl)acetamide | non-polymer | 562.0 | 2 | Chemie (A1CRW) | |||
| 4 | E, I, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) PubChem (888) | |||
| 5 | F (B) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) PubChem (311) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 169 (UniProt: P01111)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
| Ser 118 | Cys 118 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38821.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2275.4 | |
| All* | Total formula weight | 41097.3 |
