9XZI
Crystal Structure of the SUZ12-RBBP4-PHF19-EPOP PRC2.1 Subcomplex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Polycomb protein SUZ12 | polymer | 473 | 54916.3 | 1 | UniProt (Q15022) Pfam (PF23320) | Homo sapiens (human) | Chromatin precipitated E2F target 9 protein,ChET 9 protein,Joined to JAZF1 protein,Suppressor of zeste 12 protein homolog |
| 2 | B (B) | Histone-binding protein RBBP4 | polymer | 444 | 49742.7 | 1 | UniProt (Q09028) Pfam (PF12265) Pfam (PF00400) | Homo sapiens (human) | Chromatin assembly factor 1 subunit C,CAF-1 subunit C,Chromatin assembly factor I p48 subunit,CAF-I 48 kDa subunit,CAF-I p48,Nucleosome-remodeling factor subunit RBAP48,Retinoblastoma-binding protein 4,RBBP-4,Retinoblastoma-binding protein p48 |
| 3 | C (C) | PHD finger protein 19 | polymer | 53 | 5855.6 | 1 | UniProt (Q5T6S3) Pfam (PF14061) | Homo sapiens (human) | Polycomb-like protein 3,hPCL3 |
| 4 | D (D) | Elongin BC and Polycomb repressive complex 2-associated protein | polymer | 78 | 8531.6 | 1 | UniProt (A6NHQ4) Pfam (PF15223) | Homo sapiens (human) | Proline-rich protein 28 |
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 76 - 545 (UniProt: Q15022)
B: 1 - 425 (UniProt: Q09028)
C: 531 - 580 (UniProt: Q5T6S3)
D: 311 - 379 (UniProt: A6NHQ4)
| PDB | External Database | Details |
|---|---|---|
| Ser 73 | - | expression tag |
| Asn 74 | - | expression tag |
| Ala 75 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -18 | - | initiating methionine |
| Gly -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ser -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| Ser -8 | - | expression tag |
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Val -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 528 | - | expression tag |
| Asn 529 | - | expression tag |
| Ala 530 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 310 | - | expression tag |
| Asp 380 | - | expression tag |
| Tyr 381 | - | expression tag |
| Lys 382 | - | expression tag |
| Asp 383 | - | expression tag |
| Asp 384 | - | expression tag |
| Asp 385 | - | expression tag |
| Asp 386 | - | expression tag |
| Lys 387 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 119046.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 65.4 | |
| All* | Total formula weight | 119111.6 |
