9XZG
Cryo-EM structure of ALK in complex with CRBN/DDB1 and TRI-611
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Protein cereblon | polymer | 443 | 50690.8 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) | Homo sapiens (human) | |
| 2 | B (C) | ALK tyrosine kinase receptor | polymer | 323 | 36134.4 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 3 | C (B) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) PubChem (32051) | |||
| 4 | D (B) | (3S)-3-{2-oxo-5-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-1,3-benzoxazol-3(2H)-yl}piperidine-2,6-dione | non-polymer | 404.4 | 1 | Chemie (A1CRM) |
Sequence modifications
B: 1 - 442 (UniProt: Q96SW2)
C: 1093 - 1410 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 1088 | - | expression tag |
| Pro 1089 | - | expression tag |
| Gly 1090 | - | expression tag |
| Gly 1091 | - | expression tag |
| Ser 1092 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 86825.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 469.8 | |
| All* | Total formula weight | 87295.0 |
