9XYB

Crystal structure of a ZIKV E glycoprotein DI-DIII vaccine candidate in complex with human neutralizing antibody MZ4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	Human MZ4 Fab heavy chain	polymer	219	23371.0	1		Homo sapiens
2	B (L)	Human MZ4 Fab light chain	polymer	214	22799.3	1		Homo sapiens
3	C (E)	Envelope protein E	polymer	277	29375.1	1	UniProt (A0A024B7W1)	Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013
4	D (E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG) PubChem (24139)
5	E (E)	water	water		18.0	1	Chemie (HOH)

Sequence modifications

E: 1 - 126 (UniProt: A0A024B7W1)
E: 135 - 277 (UniProt: A0A024B7W1)

PDB	External Database	Details
Gly 127	-	linker
Gly 128	-	linker
Gly 129	-	linker
Gly 130	-	linker
Gly 131	-	linker
Gly 132	-	linker
Gly 133	-	linker
Gly 134	-	linker

E: 286 - 405 (UniProt: A0A024B7W1)

PDB	External Database	Details
Gly 278	-	linker
Gly 279	-	linker
Gly 280	-	linker
Gly 281	-	linker
Gly 282	-	linker
Gly 283	-	linker
Gly 284	-	linker
Gly 285	-	linker
Gly 406	-	expression tag
Gly 407	-	expression tag
Gly 408	-	expression tag
Ser 409	-	expression tag
Gly 410	-	expression tag
Leu 411	-	expression tag
Asn 412	-	expression tag
Asp 413	-	expression tag
Ile 414	-	expression tag
Phe 415	-	expression tag
Glu 416	-	expression tag
Ala 417	-	expression tag
Gln 418	-	expression tag
Lys 419	-	expression tag
Ile 420	-	expression tag
Glu 421	-	expression tag
Trp 422	-	expression tag
His 423	-	expression tag
Glu 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
His 427	-	expression tag
His 428	-	expression tag
His 429	-	expression tag
His 430	-	expression tag
His 431	-	expression tag
His 432	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	75545.3
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	75766.6

*Water molecules are not included.