9XRI
Crystal structure of MTH1 in complex with acoramidis bound at the active site and protein-protein interface (molar ratio 1:24)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Oxidized purine nucleoside triphosphate hydrolase | polymer | 156 | 18027.5 | 2 | UniProt (P36639) | Homo sapiens (human) | 2-hydroxy-dATP diphosphatase,7,8-dihydro-8-oxoguanine triphosphatase,8-oxo-dGTPase,Methylated purine nucleoside triphosphate hydrolase,Nucleoside diphosphate-linked moiety X motif 1,Nudix motif 1 |
| 2 | C, D, E, F, G... (A, B) | 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid | non-polymer | 292.3 | 6 | Chemie (16V) | |||
| 3 | I, J (A, B) | water | water | 18.0 | 407 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 156 (UniProt: P36639)
| PDB | External Database | Details |
|---|---|---|
| Lys 2 | Gly 2 | conflict |
| Ser 104 | Cys 104 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36055.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1753.8 | |
| All* | Total formula weight | 37808.9 |
