9XI9

SARS-CoV-2 Omicron LP.8.1 spike trimer (S-6P) in complex with 3 ZL58 Fabs and 3 ZL525 Fabs, focused refinement of RBD and Fab region

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Heavy chain of ZL525 Fab	polymer	228	24189.1	1		Homo sapiens (human)
2	B (B)	Light chain of ZL525 Fab	polymer	217	22890.3	1		Homo sapiens (human)
3	C (H)	Heavy chain of ZL58 Fab	polymer	221	23329.0	1		Homo sapiens (human)
4	D (C)	Spike protein S1	polymer	195	22062.9	1	UniProt (P0DTC2)	Severe acute respiratory syndrome coronavirus 2
5	E (L)	Light chain of ZL58 Fab	polymer	214	23467.0	1		Homo sapiens (human)
6	F (D)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)

Sequence modifications

C: 333 - 527 (UniProt: P0DTC2)

PDB	External Database	Details
Val 332	-	expression tag
His 339	Gly 339	variant
Thr 346	Arg 346	variant
Thr 356	Lys 356	variant
Phe 371	Ser 371	variant
Pro 373	Ser 373	variant
Phe 375	Ser 375	variant
Ala 376	Thr 376	variant
Lys 403	Arg 403	variant
Asn 405	Asp 405	variant
Ser 408	Arg 408	variant
Asn 417	Lys 417	variant
Lys 440	Asn 440	variant
Arg 445	Val 445	variant
Ser 446	Gly 446	variant
Asp 450	Asn 450	variant
Trp 452	Leu 452	variant
Ser 455	Leu 455	variant
Leu 456	Phe 456	variant
Lys 460	Asn 460	variant
Asn 477	Ser 477	variant
Lys 478	Thr 478	variant
Lys 481	Asn 481	variant
-	Val 483	deletion
Lys 484	Glu 484	variant
Pro 486	Phe 486	variant
Glu 493	Gln 493	variant
Arg 498	Gln 498	variant
Tyr 501	Asn 501	variant
His 505	Tyr 505	variant

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	115938.3
Branched	Number of molecules	1
	Total formula weight	586.5
All*	Total formula weight	116524.8

*Water molecules are not included.