9XHI
Structure of the CCL21-CCR7-Gi-scFv16 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | C-C motif chemokine 21 | polymer | 126 | 13652.8 | 1 | UniProt (O00585) Pfam (PF00048) | Homo sapiens (human) | 6Ckine,Beta-chemokine exodus-2,Secondary lymphoid-tissue chemokine,SLC,Small-inducible cytokine A21 |
| 2 | B (R) | C-C chemokine receptor type 7,Non structural polyprotein | polymer | 551 | 61585.0 | 1 | UniProt (P32248) UniProt (A0A482LYE4) Pfam (PF00001) | Homo sapiens (human) | C-C CKR-7,CC-CKR-7,CCR-7,BLR2,CDw197,Epstein-Barr virus-induced G-protein coupled receptor 1,EBI1,EBV-induced G-protein coupled receptor 1,MIP-3 beta receptor |
| 3 | C, E (A, C) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 432 | 48640.4 | 2 | UniProt (P59768) UniProt (P63097) Pfam (PF00631) Pfam (PF00503) | Homo sapiens (human) | G gamma-I,Adenylate cyclase-inhibiting G alpha protein |
| 4 | D (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40039.6 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 5 | F (D) | Antibody fragment scFv16 | polymer | 256 | 27340.5 | 1 | Mus musculus | ||
| 6 | G (R) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) PubChem (5997) |
Sequence modifications
L: 1 - 111 (UniProt: O00585)
R: 25 - 378 (UniProt: P32248)
R: 396 - 552 (UniProt: A0A482LYE4)
A, C: -77 - -8 (UniProt: P59768)
A, C: 2 - 354 (UniProt: P63097)
B: 1 - 339 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Gly 112 | - | expression tag |
| Ser 113 | - | expression tag |
| Gly 114 | - | expression tag |
| Ser 115 | - | expression tag |
| Gly 116 | - | expression tag |
| Ser 117 | - | expression tag |
| Ala 118 | - | expression tag |
| Ala 119 | - | expression tag |
| Ala 120 | - | expression tag |
| Leu 121 | - | expression tag |
| Glu 122 | - | expression tag |
| Val 123 | - | expression tag |
| Leu 124 | - | expression tag |
| Phe 125 | - | expression tag |
| Gln 126 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp 16 | - | expression tag |
| Tyr 17 | - | expression tag |
| Lys 18 | - | expression tag |
| Asp 19 | - | expression tag |
| Asp 20 | - | expression tag |
| Asp 21 | - | expression tag |
| Asp 22 | - | expression tag |
| Gly 23 | - | expression tag |
| Ser 24 | - | expression tag |
| Ser 379 | - | linker |
| Arg 380 | - | linker |
| Gly 381 | - | linker |
| Ser 382 | - | linker |
| Ser 383 | - | linker |
| Gly 384 | - | linker |
| Gly 385 | - | linker |
| Gly 386 | - | linker |
| Gly 387 | - | linker |
| Ser 388 | - | linker |
| Gly 389 | - | linker |
| Gly 390 | - | linker |
| Gly 391 | - | linker |
| Gly 392 | - | linker |
| Ser 393 | - | linker |
| Ser 394 | - | linker |
| Gly 395 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Glu 407 | Arg 83 | conflict |
| Ala 411 | Gly 87 | conflict |
| Leu 427 | Phe 103 | conflict |
| Ala 431 | Gly 107 | conflict |
| Arg 442 | Leu 118 | conflict |
| Ala 447 | Gly 123 | conflict |
| Ala 463 | Gly 139 | conflict |
| Ala 467 | Gly 143 | conflict |
| Glu 471 | Lys 147 | conflict |
| Val 472 | Ile 148 | conflict |
| Pro 489 | His 165 | conflict |
| Leu 503 | Ile 179 | conflict |
| Asn 504 | Asp 180 | conflict |
| Thr 540 | Asn 216 | conflict |
| Met 545 | Leu 221 | conflict |
| Ser 553 | - | expression tag |
| Gly 554 | - | expression tag |
| Gly 555 | - | expression tag |
| Gly 556 | - | expression tag |
| Gly 557 | - | expression tag |
| Ser 558 | - | expression tag |
| His 559 | - | expression tag |
| His 560 | - | expression tag |
| His 561 | - | expression tag |
| His 562 | - | expression tag |
| His 563 | - | expression tag |
| His 564 | - | expression tag |
| His 565 | - | expression tag |
| His 566 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -7 | - | linker |
| Ser -6 | - | linker |
| Ala -5 | - | linker |
| Gly -4 | - | linker |
| Ser -3 | - | linker |
| Ala -2 | - | linker |
| Gly -1 | - | linker |
| Ser 0 | - | linker |
| Ala 1 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asn 47 | Ser 47 | conflict |
| Ala 203 | Gly 203 | conflict |
| Ala 245 | Glu 245 | conflict |
| Ser 326 | Ala 326 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Gly 340 | - | expression tag |
| Ser 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Gly 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Ser 347 | - | expression tag |
| Gly 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Ser 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Gly 354 | - | expression tag |
| Val 355 | - | expression tag |
| Ser 356 | - | expression tag |
| Gly 357 | - | expression tag |
| Trp 358 | - | expression tag |
| Arg 359 | - | expression tag |
| Leu 360 | - | expression tag |
| Phe 361 | - | expression tag |
| Lys 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Ile 364 | - | expression tag |
| Ser 365 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 239898.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 386.7 | |
| All* | Total formula weight | 240285.3 |
