9XFI

Cryo-EM structure of the Bavachalcone bound FFAR4-Giq complex

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Free fatty acid receptor 4	polymer	361	40533.2	1	UniProt (Q5NUL3)	Homo sapiens (human)	G-protein coupled receptor 120,G-protein coupled receptor 129,G-protein coupled receptor GT01,G-protein coupled receptor PGR4,Omega-3 fatty acid receptor 1
2	B (C)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	353	39020.7	1	UniProt (P62873)	Homo sapiens (human)	Transducin beta chain 1
3	C (D)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768)	Homo sapiens (human)	G gamma-I
4	D (B)	Guanine nucleotide-binding protein G(i) subunit alpha-1,Guanine nucleotide-binding protein G(q) subunit alpha	polymer	354	40555.2	1	UniProt (P63096) UniProt (P50148)	Homo sapiens (human)	Adenylate cyclase-inhibiting G alpha protein,Guanine nucleotide-binding protein alpha-q
5	E (A)	(~{E})-3-(4-hydroxyphenyl)-1-[5-(3-methylbut-2-enyl)-2,4-bis(oxidanyl)phenyl]prop-2-en-1-one	non-polymer		324.4	1	Chemie (A1EZZ)

Sequence modifications

C: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -12	-	initiating methionine
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag

B: 1 - 325 (UniProt: P63096)

PDB	External Database	Details
Ala 203	Gly 203	conflict
Ser 326	-	linker

B: 327 - 354 (UniProt: P50148)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	127970.2
Non-Polymers*	Number of molecules	1
	Total formula weight	324.4
All*	Total formula weight	128294.6

*Water molecules are not included.