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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9X74

Human GPR30 -Gq complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(B)		Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer37440470.11UniProt (P54311)Rattus norvegicus (Norway rat)Transducin beta chain 1
2B
(G)		Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer687563.81UniProt (P59768)Homo sapiens (human)G gamma-I
3C
(A)		Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer25829027.81UniProt (P04899)
UniProt (P04896)		Homo sapiens (domestic cattle)Adenylate cyclase-inhibiting G alpha protein,Adenylate cyclase-stimulating G alpha protein
4D
(R)		G-protein coupled estrogen receptor 1polymer85094326.91UniProt (Q99527)Homo sapiens (human)Chemoattractant receptor-like 2,Flow-induced endothelial G-protein coupled receptor 1,FEG-1,G protein-coupled estrogen receptor 1,G-protein coupled receptor 30,GPCR-Br,IL8-related receptor DRY12,Lymphocyte-derived G-protein coupled receptor,LYGPR,Membrane estrogen receptor,mER
5E
(S)		scFv16polymer26027720.81Mus musculus
Sequence modifications
B: 2 - 340 (UniProt: P54311)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
Gln -1-expression tag
Leu 0-expression tag
Gln 1-expression tag
Gly 341-expression tag
Ala 342-expression tag
Ser 343-expression tag
Gly 344-expression tag
Gly 345-expression tag
Gly 346-expression tag
Ser 347-expression tag
Gly 348-expression tag
Gly 349-expression tag
Asn 350-expression tag
Ser 351-expression tag
Gly 352-expression tag
Ser 353-expression tag
Ser 354-expression tag
Gly 355-expression tag
Gly 356-expression tag
Ser 357-expression tag
Ser 358-expression tag
Gly 359-expression tag
Val 360-expression tag
Ser 361-expression tag
Gly 362-expression tag
Trp 363-expression tag
Arg 364-expression tag
Leu 365-expression tag
Phe 366-expression tag
Lys 367-expression tag
Lys 368-expression tag
Ile 369-expression tag
Ser 370-expression tag
A: 1 - 57 (UniProt: P04899)
PDBExternal DatabaseDetails
Ala -11-expression tag
Ile -10-expression tag
Leu -9-expression tag
Gly -8-expression tag
Ser -7-expression tag
Ala -6-expression tag
Gly -5-expression tag
Ser -4-expression tag
Ala -3-expression tag
Gly -2-expression tag
Ser -1-expression tag
Ala 0-expression tag
Ser 3Cys 3engineered mutation
Arg 31Ala 31engineered mutation
Thr 33Glu 33engineered mutation
Leu 34Val 34engineered mutation
Arg 35Lys 35engineered mutation
Asp 42Gly 42engineered mutation
Asn 43Glu 43engineered mutation
Arg 54Lys 54engineered mutation
Leu 56Ile 56engineered mutation
Gly 58-linker
Gly 59-linker
Ser 60-linker
Gly 61-linker
Gly 62-linker
Ser 63-linker
Gly 64-linker
Gly 65-linker
A: 66 - 246 (UniProt: P04896)
PDBExternal DatabaseDetails
Asp 111Ala 249engineered mutation
Asp 114Ser 252engineered mutation
-Asn 254deletion
-Met 255deletion
-Val 256deletion
-Ile 257deletion
-Arg 258deletion
-Glu 259deletion
-Asp 260deletion
-Asn 261deletion
-Gln 262deletion
-Thr 263deletion
Asp 124Leu 272engineered mutation
Lys 195Asp 343engineered mutation
Val 198Leu 346engineered mutation
Asp 199Arg 347engineered mutation
Ile 210Tyr 358engineered mutation
Ala 224Ile 372engineered mutation
Ile 227Val 375engineered mutation
Lys 232Arg 380engineered mutation
Leu 236Gln 384engineered mutation
Gln 237Arg 385engineered mutation
Asn 239His 387engineered mutation
Glu 242Gln 390engineered mutation
Asn 244Glu 392engineered mutation
Val 246Leu 394engineered mutation
R: 2 - 375 (UniProt: Q99527)
PDBExternal DatabaseDetails
Met -22-initiating methionine
Lys -21-expression tag
Thr -20-expression tag
Ile -19-expression tag
Ile -18-expression tag
Ala -17-expression tag
Leu -16-expression tag
Ser -15-expression tag
Tyr -14-expression tag
Ile -13-expression tag
Phe -12-expression tag
Cys -11-expression tag
Leu -10-expression tag
Val -9-expression tag
Phe -8-expression tag
Ala -7-expression tag
Asp -6-expression tag
Tyr -5-expression tag
Lys -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Asp -1-expression tag
Asp 0-expression tag
Lys 1-expression tag
Gly 376-expression tag
Ser 377-expression tag
Gly 378-expression tag
Gly 379-expression tag
Gly 380-expression tag
Gly 381-expression tag
Ser 382-expression tag
Gly 383-expression tag
Gly 384-expression tag
Ser 385-expression tag
Ser 386-expression tag
Ser 387-expression tag
Gly 388-expression tag
Gly 389-expression tag
Val 390-expression tag
Phe 391-expression tag
Thr 392-expression tag
Leu 393-expression tag
Glu 394-expression tag
Asp 395-expression tag
Phe 396-expression tag
Val 397-expression tag
Gly 398-expression tag
Asp 399-expression tag
Trp 400-expression tag
Glu 401-expression tag
Gln 402-expression tag
Thr 403-expression tag
Ala 404-expression tag
Ala 405-expression tag
Tyr 406-expression tag
Asn 407-expression tag
Leu 408-expression tag
Asp 409-expression tag
Gln 410-expression tag
Val 411-expression tag
Leu 412-expression tag
Glu 413-expression tag
Gln 414-expression tag
Gly 415-expression tag
Gly 416-expression tag
Val 417-expression tag
Ser 418-expression tag
Ser 419-expression tag
Leu 420-expression tag
Leu 421-expression tag
Gln 422-expression tag
Asn 423-expression tag
Leu 424-expression tag
Ala 425-expression tag
Val 426-expression tag
Ser 427-expression tag
Val 428-expression tag
Thr 429-expression tag
Pro 430-expression tag
Ile 431-expression tag
Gln 432-expression tag
Arg 433-expression tag
Ile 434-expression tag
Val 435-expression tag
Arg 436-expression tag
Ser 437-expression tag
Gly 438-expression tag
Glu 439-expression tag
Asn 440-expression tag
Ala 441-expression tag
Leu 442-expression tag
Lys 443-expression tag
Ile 444-expression tag
Asp 445-expression tag
Ile 446-expression tag
His 447-expression tag
Val 448-expression tag
Ile 449-expression tag
Ile 450-expression tag
Pro 451-expression tag
Tyr 452-expression tag
Glu 453-expression tag
Gly 454-expression tag
Leu 455-expression tag
Ser 456-expression tag
Ala 457-expression tag
Asp 458-expression tag
Gln 459-expression tag
Met 460-expression tag
Ala 461-expression tag
Gln 462-expression tag
Ile 463-expression tag
Glu 464-expression tag
Glu 465-expression tag
Val 466-expression tag
Phe 467-expression tag
Lys 468-expression tag
Val 469-expression tag
Val 470-expression tag
Tyr 471-expression tag
Pro 472-expression tag
Val 473-expression tag
Asp 474-expression tag
Asp 475-expression tag
His 476-expression tag
His 477-expression tag
Phe 478-expression tag
Lys 479-expression tag
Val 480-expression tag
Ile 481-expression tag
Leu 482-expression tag
Pro 483-expression tag
Tyr 484-expression tag
Gly 485-expression tag
Thr 486-expression tag
Leu 487-expression tag
Val 488-expression tag
Ile 489-expression tag
Asp 490-expression tag
Gly 491-expression tag
Val 492-expression tag
Thr 493-expression tag
Pro 494-expression tag
Asn 495-expression tag
Met 496-expression tag
Leu 497-expression tag
Asn 498-expression tag
Tyr 499-expression tag
Phe 500-expression tag
Gly 501-expression tag
Arg 502-expression tag
Pro 503-expression tag
Tyr 504-expression tag
Glu 505-expression tag
Gly 506-expression tag
Ile 507-expression tag
Ala 508-expression tag
Val 509-expression tag
Phe 510-expression tag
Asp 511-expression tag
Gly 512-expression tag
Lys 513-expression tag
Lys 514-expression tag
Ile 515-expression tag
Thr 516-expression tag
Val 517-expression tag
Thr 518-expression tag
Gly 519-expression tag
Thr 520-expression tag
Leu 521-expression tag
Trp 522-expression tag
Asn 523-expression tag
Gly 524-expression tag
Asn 525-expression tag
Lys 526-expression tag
Ile 527-expression tag
Ile 528-expression tag
Asp 529-expression tag
Glu 530-expression tag
Arg 531-expression tag
Leu 532-expression tag
Ile 533-expression tag
Thr 534-expression tag
Pro 535-expression tag
Asp 536-expression tag
Gly 537-expression tag
Ser 538-expression tag
Met 539-expression tag
Leu 540-expression tag
Phe 541-expression tag
Arg 542-expression tag
Val 543-expression tag
Thr 544-expression tag
Ile 545-expression tag
Asn 546-expression tag
Ser 547-expression tag
Gly 548-expression tag
Gly 549-expression tag
Ser 550-expression tag
Gly 551-expression tag
Gly 552-expression tag
Gly 553-expression tag
Gly 554-expression tag
Ser 555-expression tag
Gly 556-expression tag
Gly 557-expression tag
Ser 558-expression tag
Ser 559-expression tag
Ser 560-expression tag
Gly 561-expression tag
Gly 562-expression tag
Leu 563-expression tag
Glu 564-expression tag
Val 565-expression tag
Leu 566-expression tag
Phe 567-expression tag
Gln 568-expression tag
Gly 569-expression tag
Pro 570-expression tag
Gly 571-expression tag
Ser 572-expression tag
Ala 573-expression tag
Ala 574-expression tag
Ala 575-expression tag
Ala 576-expression tag
Val 577-expression tag
Ser 578-expression tag
Lys 579-expression tag
Gly 580-expression tag
Glu 581-expression tag
Glu 582-expression tag
Leu 583-expression tag
Phe 584-expression tag
Thr 585-expression tag
Gly 586-expression tag
Val 587-expression tag
Val 588-expression tag
Pro 589-expression tag
Ile 590-expression tag
Leu 591-expression tag
Val 592-expression tag
Glu 593-expression tag
Leu 594-expression tag
Asp 595-expression tag
Gly 596-expression tag
Asp 597-expression tag
Val 598-expression tag
Asn 599-expression tag
Gly 600-expression tag
His 601-expression tag
Lys 602-expression tag
Phe 603-expression tag
Ser 604-expression tag
Val 605-expression tag
Ser 606-expression tag
Gly 607-expression tag
Glu 608-expression tag
Gly 609-expression tag
Glu 610-expression tag
Gly 611-expression tag
Asp 612-expression tag
Ala 613-expression tag
Thr 614-expression tag
Tyr 615-expression tag
Gly 616-expression tag
Lys 617-expression tag
Leu 618-expression tag
Thr 619-expression tag
Leu 620-expression tag
Lys 621-expression tag
Phe 622-expression tag
Ile 623-expression tag
Cys 624-expression tag
Thr 625-expression tag
Thr 626-expression tag
Gly 627-expression tag
Lys 628-expression tag
Leu 629-expression tag
Pro 630-expression tag
Val 631-expression tag
Pro 632-expression tag
Trp 633-expression tag
Pro 634-expression tag
Thr 635-expression tag
Leu 636-expression tag
Val 637-expression tag
Thr 638-expression tag
Thr 639-expression tag
Leu 640-expression tag
Thr 641-expression tag
Tyr 642-expression tag
Gly 643-expression tag
Val 644-expression tag
Gln 645-expression tag
Cys 646-expression tag
Phe 647-expression tag
Ser 648-expression tag
Arg 649-expression tag
Tyr 650-expression tag
Pro 651-expression tag
Asp 652-expression tag
His 653-expression tag
Met 654-expression tag
Lys 655-expression tag
Gln 656-expression tag
His 657-expression tag
Asp 658-expression tag
Phe 659-expression tag
Phe 660-expression tag
Lys 661-expression tag
Ser 662-expression tag
Ala 663-expression tag
Met 664-expression tag
Pro 665-expression tag
Glu 666-expression tag
Gly 667-expression tag
Tyr 668-expression tag
Val 669-expression tag
Gln 670-expression tag
Glu 671-expression tag
Arg 672-expression tag
Thr 673-expression tag
Ile 674-expression tag
Phe 675-expression tag
Phe 676-expression tag
Lys 677-expression tag
Asp 678-expression tag
Asp 679-expression tag
Gly 680-expression tag
Asn 681-expression tag
Tyr 682-expression tag
Lys 683-expression tag
Thr 684-expression tag
Arg 685-expression tag
Ala 686-expression tag
Glu 687-expression tag
Val 688-expression tag
Lys 689-expression tag
Phe 690-expression tag
Glu 691-expression tag
Gly 692-expression tag
Asp 693-expression tag
Thr 694-expression tag
Leu 695-expression tag
Val 696-expression tag
Asn 697-expression tag
Arg 698-expression tag
Ile 699-expression tag
Glu 700-expression tag
Leu 701-expression tag
Lys 702-expression tag
Gly 703-expression tag
Ile 704-expression tag
Asp 705-expression tag
Phe 706-expression tag
Lys 707-expression tag
Glu 708-expression tag
Asp 709-expression tag
Gly 710-expression tag
Asn 711-expression tag
Ile 712-expression tag
Leu 713-expression tag
Gly 714-expression tag
His 715-expression tag
Lys 716-expression tag
Leu 717-expression tag
Glu 718-expression tag
Tyr 719-expression tag
Asn 720-expression tag
Tyr 721-expression tag
Asn 722-expression tag
Ser 723-expression tag
His 724-expression tag
Asn 725-expression tag
Val 726-expression tag
Tyr 727-expression tag
Ile 728-expression tag
Met 729-expression tag
Ala 730-expression tag
Asp 731-expression tag
Lys 732-expression tag
Gln 733-expression tag
Lys 734-expression tag
Asn 735-expression tag
Gly 736-expression tag
Ile 737-expression tag
Lys 738-expression tag
Val 739-expression tag
Asn 740-expression tag
Phe 741-expression tag
Lys 742-expression tag
Ile 743-expression tag
Arg 744-expression tag
His 745-expression tag
Asn 746-expression tag
Ile 747-expression tag
Glu 748-expression tag
Asp 749-expression tag
Gly 750-expression tag
Ser 751-expression tag
Val 752-expression tag
Gln 753-expression tag
Leu 754-expression tag
Ala 755-expression tag
Asp 756-expression tag
His 757-expression tag
Tyr 758-expression tag
Gln 759-expression tag
Gln 760-expression tag
Asn 761-expression tag
Thr 762-expression tag
Pro 763-expression tag
Ile 764-expression tag
Gly 765-expression tag
Asp 766-expression tag
Gly 767-expression tag
Pro 768-expression tag
Val 769-expression tag
Leu 770-expression tag
Leu 771-expression tag
Pro 772-expression tag
Asp 773-expression tag
Asn 774-expression tag
His 775-expression tag
Tyr 776-expression tag
Leu 777-expression tag
Ser 778-expression tag
Thr 779-expression tag
Gln 780-expression tag
Ser 781-expression tag
Lys 782-expression tag
Leu 783-expression tag
Ser 784-expression tag
Lys 785-expression tag
Asp 786-expression tag
Pro 787-expression tag
Asn 788-expression tag
Glu 789-expression tag
Lys 790-expression tag
Arg 791-expression tag
Asp 792-expression tag
His 793-expression tag
Met 794-expression tag
Val 795-expression tag
Leu 796-expression tag
Leu 797-expression tag
Glu 798-expression tag
Phe 799-expression tag
Val 800-expression tag
Thr 801-expression tag
Ala 802-expression tag
Ala 803-expression tag
Gly 804-expression tag
Ile 805-expression tag
Thr 806-expression tag
Leu 807-expression tag
Gly 808-expression tag
Met 809-expression tag
Asp 810-expression tag
Glu 811-expression tag
Leu 812-expression tag
Tyr 813-expression tag
Lys 814-expression tag
Ser 815-expression tag
Gly 816-expression tag
Leu 817-expression tag
Arg 818-expression tag
Ser 819-expression tag
His 820-expression tag
His 821-expression tag
His 822-expression tag
His 823-expression tag
His 824-expression tag
His 825-expression tag
His 826-expression tag
His 827-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight199109.4
All*Total formula weight199109.4
*Water molecules are not included.

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PDB entries from 2026-08-26

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