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9X65

Cryo-EM structure of the human KCNQ2/3 heteromer channel in the XEN1101-bound open state

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(E, F, G, H)
Calmodulin-1polymer14916852.54UniProt (P0DP23)Homo sapiens (human)
2E, F, G
(A, B, C)
Potassium voltage-gated channel subfamily KQT member 3polymer87296866.43UniProt (O43525)Homo sapiens (human)KQT-like 3,Potassium channel subunit alpha KvLQT3,Voltage-gated potassium channel subunit Kv7.3
3H
(D)
Potassium voltage-gated channel subfamily KQT member 2polymer87295976.71UniProt (O43526)Homo sapiens (human)KQT-like 2,Neuroblastoma-specific potassium channel subunit alpha KvLQT2,Voltage-gated potassium channel subunit Kv7.2
4I, M, O, R
(A, B, C, D)
Azetukalnernon-polymer368.54Chemie (A1EY8)
5J, N, P, S
(A, B, C, D)
[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoatenon-polymer746.64Chemie (PIO)
6K, L, Q
(A, C)
POTASSIUM IONnon-polymer39.13Chemie (K)
PubChem (813)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains8
Total formula weight453986.1
Non-Polymers*Number of molecules11
Total formula weight4577.5
All*Total formula weight458563.6
*Water molecules are not included.

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PDB entries from 2026-05-27

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