9WSW
Cryo-EM structure of endomorphin-1-muOR-Gz-scFv16 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Engineered guanine nucleotide-binding protein G(z) subunit alpha | polymer | 355 | 40699.5 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P19086) | Homo sapiens | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40039.6 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (R) | Mu-type opioid receptor,Vasopressin V2 receptor | polymer | 386 | 42836.3 | 1 | UniProt (P42866) UniProt (P30518) Pfam (PF00001) | Mus musculus (house mouse) | M-OR-1,MOR-1,V2R,AVPR V2,Antidiuretic hormone receptor,Renal-type arginine vasopressin receptor |
| 5 | E (P) | endomorphin-1 | polymer | 5 | 609.7 | 1 | synthetic construct | ||
| 6 | F, G (R, P) | water | water | 18.0 | 2 | Chemie (HOH) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
R: 6 - 352 (UniProt: P42866)
R: 353 - 382 (UniProt: P30518)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| Pro 4 | - | expression tag |
| Met 5 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Leu 383 | - | expression tag |
| Glu 384 | - | expression tag |
| Val 385 | - | expression tag |
| Leu 386 | - | expression tag |
| Phe 387 | - | expression tag |
| Gln 388 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 132046.3 | |
| All* | Total formula weight | 132046.3 |
