9WS4

Cyro-EM structure of the ACT-451840-bound PfMDR1

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Multidrug resistance protein 1	polymer	1461	166659.9	1	UniProt (Q7K6A5) Pfam (PF00664) Pfam (PF00005)	Plasmodium falciparum 3D7	PfMDR1,P-glycoprotein homolog,PGH1
2	B (A)	ACT-451840	non-polymer		751.0	1	Chemie (A1EYJ)

Sequence modifications

A: 1 - 1419 (UniProt: Q7K6A5)

PDB	External Database	Details
Met -41	-	initiating methionine
Gly -40	-	expression tag
Ser -39	-	expression tag
Trp -38	-	expression tag
Ser -37	-	expression tag
His -36	-	expression tag
Pro -35	-	expression tag
Gln -34	-	expression tag
Phe -33	-	expression tag
Glu -32	-	expression tag
Lys -31	-	expression tag
Gly -30	-	expression tag
Gly -29	-	expression tag
Gly -28	-	expression tag
Ser -27	-	expression tag
Gly -26	-	expression tag
Gly -25	-	expression tag
Gly -24	-	expression tag
Ser -23	-	expression tag
Gly -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Ala -19	-	expression tag
Trp -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
Pro -15	-	expression tag
Gln -14	-	expression tag
Phe -13	-	expression tag
Glu -12	-	expression tag
Lys -11	-	expression tag
Ser -10	-	linker
Gly -9	-	linker
Asp -8	-	linker
Glu -7	-	linker
Val -6	-	linker
Asp -5	-	linker
Ala -4	-	linker
Ser -3	-	linker
Ser -2	-	linker
Gly -1	-	linker
Arg 0	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	166659.9
Non-Polymers*	Number of molecules	1
	Total formula weight	751.0
All*	Total formula weight	167410.8

*Water molecules are not included.