9WNG
5HT2BR-fab heterotrimer in complex with a novel antagonist IHCH-2330
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | P2C2 Fab light chain | polymer | 236 | 25687.9 | 1 | Homo sapiens | ||
| 2 | B (C) | P2C2 Fab heavy chain | polymer | 270 | 29321.9 | 1 | Homo sapiens | ||
| 3 | C (R) | 5-hydroxytryptamine receptor 2B | polymer | 307 | 34342.7 | 1 | UniProt (P41595) | Homo sapiens (human) | 5-HT-2B,5-HT2B,Serotonin receptor 2B |
| 4 | D (R) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) PubChem (24139) | |||
| 5 | E (R) | 3-[2-[2-[2,5-dimethoxy-4-(trifluoromethyl)phenyl]ethyl-methyl-amino]ethyl]-2-methyl-pyrido[1,2-a]pyrimidin-4-one | non-polymer | 449.5 | 1 | Chemie (A1EXY) |
Sequence modifications
R: 36 - 306 (UniProt: P41595)
R: 314 - 394 (UniProt: P41595)
| PDB | External Database | Details |
|---|---|---|
| Gly 29 | - | expression tag |
| Pro 30 | - | expression tag |
| Gly 31 | - | expression tag |
| Ser 32 | - | expression tag |
| Gly 33 | - | expression tag |
| Ser 34 | - | expression tag |
| Gly 35 | - | expression tag |
| Trp 144 | Met 144 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 307 | - | linker |
| Leu 308 | - | linker |
| Leu 309 | - | linker |
| Ser 310 | - | linker |
| Gly 311 | - | linker |
| Ser 312 | - | linker |
| Arg 313 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 89352.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 670.7 | |
| All* | Total formula weight | 90023.2 |
