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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9WMS

Co-transcriptional histone H3K36 methylation complex containing RNA polymerase II elongation complex, Set2, and the upstream nucleosome. (temp115, type B)

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		DNA-directed RNA polymerase subunitpolymer1743194107.41UniProt (C4R4Y0)
Pfam (PF04997)
Pfam (PF05001)
Pfam (PF00623)
Pfam (PF04983)
Pfam (PF05000)
Pfam (PF04998)
Pfam (PF04992)
Pfam (PF04990)		Komagataella phaffii GS115RNA polymerase II subunit Rpb1
2B
(B)		DNA-directed RNA polymerase subunit betapolymer1227139746.11UniProt (C4QZQ7)
Pfam (PF04563)
Pfam (PF04561)
Pfam (PF04565)
Pfam (PF04566)
Pfam (PF04567)
Pfam (PF00562)
Pfam (PF04560)		Komagataella phaffii GS115RNA polymerase II subunit Rpb2
3C
(C)		RNA polymerase II third largest subunit B44, part of central corepolymer30434216.31UniProt (C4R7L2)
Pfam (PF01193)
Pfam (PF01000)		Komagataella phaffii GS115RNA polymerase II subunit Rpb3
4D
(D)		RNA polymerase II subunit B32polymer18620623.01UniProt (C4R2U9)
Pfam (PF03874)		Komagataella phaffii GS115RNA polymerase II subunit Rpb4
5E
(E)		DNA-directed RNA polymerases I, II, and III subunit RPABC1polymer21424962.71UniProt (C4R3P8)
Pfam (PF03871)
Pfam (PF01191)		Komagataella phaffii GS115RNA polymerase II subunit Rpb5
6F
(F)		RNA polymerase subunit ABC23, common to RNA polymerases I, II, and IIIpolymer15517803.61UniProt (C4R1V1)
Pfam (PF01192)		Komagataella phaffii GS115RNA polymerase II subunit Rpb6
7G
(G)		RNA polymerase II subunitpolymer17118802.61UniProt (C4R9A1)
Pfam (PF03876)
Pfam (PF00575)		Komagataella phaffii GS115RNA polymerase II subunit Rpb7
8H
(H)		DNA-directed RNA polymerases I, II, and III subunit RPABC3polymer14516249.21UniProt (C4R273)
Pfam (PF03870)		Komagataella phaffii GS115RNA polymerase II subunit Rpb8
9I
(I)		DNA-directed RNA polymerase subunitpolymer11513612.31UniProt (F2QPE6)
Pfam (PF02150)
Pfam (PF01096)		Komagataella phaffii GS115
10J
(J)		RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and IIIpolymer728554.11UniProt (C4R009)
Pfam (PF01194)		Komagataella phaffii GS115RNA polymerase II subunit Rpb10
11K
(K)		RNA polymerase II subunit B12.5polymer11813832.91UniProt (C4R3Z5)
Pfam (PF13656)		Komagataella phaffii GS115RNA polymerase II subunit Rpb11
12L
(L)		RNA polymerase subunit ABC10-alphapolymer727862.01UniProt (F2QMI1)
Pfam (PF03604)		Komagataella phaffii GS115RNA polymerase II subunit Rpb12
13M
(M)		Transcription elongation factor 1 homologpolymer11312606.91UniProt (C4QZ45)
Pfam (PF05129)		Komagataella phaffii GS115
14N
(N)		DNA (198-MER)polymer19861264.71synthetic construct
15O
(P)		RNA (5'-R(P*GP*CP*UP*UP*GP*UP*GP*CP*UP*GP*UP*CP*UP*UP*CP*GP*UP*CP*CP*A)-3')polymer206290.71synthetic construct
16P
(T)		DNA (198-MER)polymer19860987.21synthetic construct
17Q
(V)		Transcription elongation factor SPT4polymer10812039.61UniProt (C4R0E6)
Pfam (PF06093)		Komagataella phaffii GS115
18R
(W)		Transcription elongation factor SPT5polymer911101459.41UniProt (C4R370)
Pfam (PF11942)
Pfam (PF03439)
Pfam (PF00467)
Pfam (PF12815)		Komagataella phaffii GS115Chromatin Elongation factor SPT5,Transcription elongation factor spt5
19S
(m)		Transcription elongation factor Spt6polymer1503173241.61UniProt (C4R7H2)
Pfam (PF14632)
Pfam (PF14641)
Pfam (PF22706)
Pfam (PF14639)
Pfam (PF14635)
Pfam (PF21710)
Pfam (PF14633)		Komagataella phaffii GS115
20T
(n)		Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase IIpolymer41746907.81UniProt (C4R7L8)
Pfam (PF08711)		Komagataella phaffii GS115
21U
(q)		Component of the Paf1p complexpolymer1084124979.01UniProt (C4R6B2)
Pfam (PF13432)		Komagataella phaffii GS115
22V
(r)		RNAPII-associated chromatin remodeling Paf1 complex subunitpolymer54462301.21UniProt (F2QQ42)
Pfam (PF03126)		Komagataella phaffii GS115
23W
(s)		Histone-lysine N-methyltransferase, H3 lysine-36 specificpolymer72583724.51UniProt (C4QY01)
Pfam (PF17907)
Pfam (PF00856)
Pfam (PF00397)
Pfam (PF08236)		Komagataella phaffii GS115SET domain-containing protein 2
24X
(u)		Leo1polymer45952387.71UniProt (C4R3K1)
Pfam (PF04004)		Komagataella phaffii GS115
25Y
(v)		RNAP II-associated proteinpolymer39646046.01UniProt (C4R997)
Pfam (PF03985)		Komagataella phaffii GS115
26Z
(x)		Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4ppolymer39544760.71UniProt (C4R1E6)
Pfam (PF05179)		Komagataella phaffii GS115
27AA, EA
(a, e)		Histone H3.3polymer13915645.32UniProt (P84243)
Pfam (PF00125)		Homo sapiens (human)
28BA, FA
(b, f)		Histone H4polymer10611676.72UniProt (P62805)
Pfam (PF15511)		Homo sapiens (human)
29CA, GA
(c, g)		Histone H2A type 1-B/Epolymer13314447.82UniProt (P04908)
Pfam (PF00125)
Pfam (PF16211)		Homo sapiens (human)Histone H2A.2,Histone H2A/a,Histone H2A/m
30DA, HA
(d, h)		Histone H2B type 1-Jpolymer12914191.52UniProt (P06899)
Pfam (PF00125)		Homo sapiens (human)Histone H2B.1,Histone H2B.r,H2B/r
31IA, JA, LA, MA, NA...
(A, B, C, I, J...)		ZINC IONnon-polymer65.413Chemie (ZN)
32KA
(A)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
33WA
(s)		S-ADENOSYL-L-HOMOCYSTEINEnon-polymer384.41Chemie (SAH)
Sequence modifications
M: 1 - 110 (UniProt: C4QZ45)
PDBExternal DatabaseDetails
Gly -2-expression tag
Pro -1-expression tag
Gly 0-expression tag
V: 8 - 114 (UniProt: C4R0E6)
PDBExternal DatabaseDetails
Met 7-initiating methionine
W: 1 - 908 (UniProt: C4R370)
PDBExternal DatabaseDetails
Gly -2-expression tag
Pro -1-expression tag
Gly 0-expression tag
m: 1 - 1500 (UniProt: C4R7H2)
PDBExternal DatabaseDetails
Gly -2-expression tag
Pro -1-expression tag
Gly 0-expression tag
n: 1 - 414 (UniProt: C4R7L8)
PDBExternal DatabaseDetails
Gly -2-expression tag
Pro -1-expression tag
Gly 0-expression tag
q: 1 - 1044 (UniProt: C4R6B2)
PDBExternal DatabaseDetails
Met -39-initiating methionine
Lys -38-expression tag
Asp -37-expression tag
His -36-expression tag
Leu -35-expression tag
Ile -34-expression tag
His -33-expression tag
Asn -32-expression tag
His -31-expression tag
His -30-expression tag
Lys -29-expression tag
His -28-expression tag
Glu -27-expression tag
His -26-expression tag
Ala -25-expression tag
His -24-expression tag
Ala -23-expression tag
Glu -22-expression tag
His -21-expression tag
Asp -20-expression tag
Tyr -19-expression tag
Lys -18-expression tag
Asp -17-expression tag
Asp -16-expression tag
Asp -15-expression tag
Asp -14-expression tag
Lys -13-expression tag
Glu -12-expression tag
His -11-expression tag
Leu -10-expression tag
Tyr -9-expression tag
Phe -8-expression tag
Gln -7-expression tag
Gly -6-expression tag
Ser -5-expression tag
Ser -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Ser -1-expression tag
Gly 0-expression tag
r: 1 - 514 (UniProt: F2QQ42)
PDBExternal DatabaseDetails
Met -29-initiating methionine
Lys -28-expression tag
Asp -27-expression tag
His -26-expression tag
Leu -25-expression tag
Ile -24-expression tag
His -23-expression tag
Asn -22-expression tag
His -21-expression tag
His -20-expression tag
Lys -19-expression tag
His -18-expression tag
Glu -17-expression tag
His -16-expression tag
Ala -15-expression tag
His -14-expression tag
Ala -13-expression tag
Glu -12-expression tag
His -11-expression tag
Leu -10-expression tag
Tyr -9-expression tag
Phe -8-expression tag
Gln -7-expression tag
Gly -6-expression tag
Ser -5-expression tag
Ser -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Ser -1-expression tag
Gly 0-expression tag
s: 1 - 722 (UniProt: C4QY01)
PDBExternal DatabaseDetails
Gly -2-expression tag
Pro -1-expression tag
Gly 0-expression tag
u: 1 - 429 (UniProt: C4R3K1)
PDBExternal DatabaseDetails
Met -29-initiating methionine
Lys -28-expression tag
Asp -27-expression tag
His -26-expression tag
Leu -25-expression tag
Ile -24-expression tag
His -23-expression tag
Asn -22-expression tag
His -21-expression tag
His -20-expression tag
Lys -19-expression tag
His -18-expression tag
Glu -17-expression tag
His -16-expression tag
Ala -15-expression tag
His -14-expression tag
Ala -13-expression tag
Glu -12-expression tag
His -11-expression tag
Leu -10-expression tag
Tyr -9-expression tag
Phe -8-expression tag
Gln -7-expression tag
Gly -6-expression tag
Ser -5-expression tag
Ser -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Ser -1-expression tag
Gly 0-expression tag
v: 1 - 393 (UniProt: C4R997)
PDBExternal DatabaseDetails
Gly -2-expression tag
Ser -1-expression tag
Ala 0-expression tag
x: 1 - 365 (UniProt: C4R1E6)
PDBExternal DatabaseDetails
Met -29-initiating methionine
Lys -28-expression tag
Asp -27-expression tag
His -26-expression tag
Leu -25-expression tag
Ile -24-expression tag
His -23-expression tag
Asn -22-expression tag
His -21-expression tag
His -20-expression tag
Lys -19-expression tag
His -18-expression tag
Glu -17-expression tag
His -16-expression tag
Ala -15-expression tag
His -14-expression tag
Ala -13-expression tag
Glu -12-expression tag
His -11-expression tag
Leu -10-expression tag
Tyr -9-expression tag
Phe -8-expression tag
Gln -7-expression tag
Gly -6-expression tag
Ser -5-expression tag
Ser -4-expression tag
Gly -3-expression tag
Ser -2-expression tag
Ser -1-expression tag
Gly 0-expression tag
a, e: 0 - 135 (UniProt: P84243)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
Met 36Lys 37variant
b, f: 0 - 102 (UniProt: P62805)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
c, g: 0 - 129 (UniProt: P04908)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
d, h: 0 - 125 (UniProt: P06899)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
Cys 120Lys 121engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains34
Total formula weight1511291.9
Non-Polymers*Number of molecules15
Total formula weight1259.0
All*Total formula weight1512550.9
*Water molecules are not included.

247536

PDB entries from 2026-01-14

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