9WKV
[M322I] Menin complexed with JNJ-75276617
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Menin | polymer | 488 | 54705.0 | 2 | UniProt (O00255) Pfam (PF05053) | Homo sapiens (human) | |
| 2 | C, G (A, B) | N-ethyl-5-fluoro-2-{[5-(2-{(3R)-6-[(2-methoxyethyl)(methyl)amino]-2-methylhexan-3-yl}-2,6-diazaspiro[3.4]octan-6-yl)-1,2,4-triazin-6-yl]oxy}-N-(propan-2-yl)benzamide | non-polymer | 599.8 | 2 | Chemie (9N6) PubChem (156498110) | |||
| 3 | D, E, H, J, K... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | F, M (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | I (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) PubChem (4478249) | |||
| 6 | N, O (A, B) | water | water | 18.0 | 565 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 457 (UniProt: O00255)
A, B: 458 - 489 (UniProt: O00255)
| PDB | External Database | Details |
|---|---|---|
| Thr 5 | Ala 5 | engineered mutation |
| Ile 322 | Met 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 109410.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1815.8 | |
| All* | Total formula weight | 111225.9 |
