9WGU

Crystal structure of Cbl-b bound to compound

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (AAA, BBB)	E3 ubiquitin-protein ligase CBL-B	polymer	388	45070.7	2	UniProt (Q13191) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) Pfam (PF00097)	Homo sapiens (human)	Casitas B-lineage lymphoma proto-oncogene b,RING finger protein 56,RING-type E3 ubiquitin transferase CBL-B,SH3-binding protein CBL-B,Signal transduction protein CBL-B
2	C, M (AAA, BBB)	2-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-7-[[(3~{S})-3-methylpiperidin-1-yl]methyl]-5-(trifluoromethyl)-3,4-dihydroisoquinolin-1-one	non-polymer		551.6	2	Chemie (A1EWZ)
3	D, E, N, O (AAA, BBB)	ZINC ION	non-polymer		65.4	4	Chemie (ZN) PubChem (32051)
4	F, P (AAA, BBB)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA) PubChem (271)
5	G, H, I, J, K... (AAA, BBB)	1,2-ETHANEDIOL	non-polymer		62.1	13	Chemie (EDO)
6	X, Y (AAA, BBB)	water	water		18.0	594	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	90141.3
Non-Polymers*	Number of molecules	21
	Total formula weight	2252.0
All*	Total formula weight	92393.3

*Water molecules are not included.