9WG6
D1R-Gs in complexed with Dopamine/LY3154207/BMSA1/UNC9815
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 246 | 29048.9 | 1 | UniProt (P63092) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 371 | 40227.0 | 1 | UniProt (P54311) | Rattus norvegicus (Norway rat) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 68 | 7563.8 | 1 | UniProt (P63212) | Bos taurus (domestic cattle) | G gamma-I |
| 4 | D (N) | Nanobody35 | polymer | 160 | 17352.5 | 1 | Vicugna pacos | ||
| 5 | E (R) | Beta-2 adrenergic receptor,D(1A) dopamine receptor,Engineered oplophorus-luciferin 2-monooxygenase catalytic subunit | polymer | 603 | 66836.8 | 1 | UniProt (P07550) UniProt (P21728) | Homo sapiens (human) | Beta-2 adrenoreceptor,Beta-2 adrenoceptor,Dopamine D1 receptor |
| 6 | F (R) | L-DOPAMINE | non-polymer | 153.2 | 1 | Chemie (LDP) PubChem (681) | |||
| 7 | G (R) | ~{N}-(3-aminocarbonyl-6-~{tert}-butyl-1-benzothiophen-2-yl)pyridine-4-carboxamide | non-polymer | 353.4 | 1 | Chemie (A1EWF) | |||
| 8 | H (R) | 1-[(1~{S},3~{R},6~{R})-6-(1,3-benzodioxol-5-yl)-3-bicyclo[4.1.0]heptanyl]-4-[(2-bromanyl-5-chloranyl-phenyl)methyl]piperazine | non-polymer | 503.9 | 1 | Chemie (A1EV3) | |||
| 9 | I (R) | 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone | non-polymer | 450.4 | 1 | Chemie (G4C) PubChem (86290953) | |||
| 10 | J, K (R) | PALMITIC ACID | non-polymer | 256.4 | 2 | Chemie (PLM) PubChem (985) | |||
| 11 | L (R) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A: 9 - 60 (UniProt: P63092)
A: 67 - 116 (UniProt: P63092)
A: 117 - 246 (UniProt: P63092)
B: 2 - 340 (UniProt: P54311)
R: -30 - -1 (UniProt: P07550)
R: 2 - 367 (UniProt: P21728)
R: 368 - 533 (PDB: 9WG6)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Gly 2 | - | expression tag |
| Cys 3 | - | expression tag |
| Leu 4 | - | expression tag |
| Gly 5 | - | expression tag |
| Asn 6 | - | expression tag |
| Ser 7 | - | expression tag |
| Lys 8 | - | expression tag |
| Met 25 | Lys 25 | conflict |
| Asp 49 | Gly 49 | conflict |
| Asn 50 | Glu 50 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 61 | - | linker |
| Ile 62 | - | linker |
| Tyr 63 | - | linker |
| His 64 | - | linker |
| Val 65 | - | linker |
| Asn 66 | - | linker |
| Ala 88 | Gly 226 | conflict |
| Asp 111 | Ala 249 | conflict |
| Asp 114 | Ser 252 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Asp 124 | Leu 272 | conflict |
| Ser 218 | Ala 366 | conflict |
| Ala 224 | Ile 372 | conflict |
| Ile 227 | Val 375 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Gly 345 | - | expression tag |
| Gly 346 | - | expression tag |
| Gly 347 | - | expression tag |
| Ser 348 | - | expression tag |
| Gly 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Gly 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Ser 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Val 356 | - | expression tag |
| Ser 357 | - | expression tag |
| Gly 358 | - | expression tag |
| Trp 359 | - | expression tag |
| Arg 360 | - | expression tag |
| Leu 361 | - | expression tag |
| Phe 362 | - | expression tag |
| Lys 363 | - | expression tag |
| Lys 364 | - | expression tag |
| Ile 365 | - | expression tag |
| Ser 366 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -69 | - | initiating methionine |
| Asp -68 | - | expression tag |
| Ser -67 | - | expression tag |
| Lys -66 | - | expression tag |
| Gly -65 | - | expression tag |
| Ser -64 | - | expression tag |
| Ser -63 | - | expression tag |
| Gln -62 | - | expression tag |
| Lys -61 | - | expression tag |
| Gly -60 | - | expression tag |
| Ser -59 | - | expression tag |
| Arg -58 | - | expression tag |
| Leu -57 | - | expression tag |
| Leu -56 | - | expression tag |
| Leu -55 | - | expression tag |
| Leu -54 | - | expression tag |
| Leu -53 | - | expression tag |
| Val -52 | - | expression tag |
| Val -51 | - | expression tag |
| Ser -50 | - | expression tag |
| Asn -49 | - | expression tag |
| Leu -48 | - | expression tag |
| Leu -47 | - | expression tag |
| Leu -46 | - | expression tag |
| Cys -45 | - | expression tag |
| Gln -44 | - | expression tag |
| Gly -43 | - | expression tag |
| Val -42 | - | expression tag |
| Val -41 | - | expression tag |
| Ser -40 | - | expression tag |
| Asp -39 | - | expression tag |
| Tyr -38 | - | expression tag |
| Lys -37 | - | expression tag |
| Asp -36 | - | expression tag |
| Asp -35 | - | expression tag |
| Asp -34 | - | expression tag |
| Asp -33 | - | expression tag |
| Val -32 | - | expression tag |
| Asp -31 | - | expression tag |
| Gln -4 | Glu 27 | conflict |
| Ala 0 | - | linker |
| Ser 1 | - | linker |
R: 368 - 533 (PDB: 9WG6)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 161028.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1973.7 | |
| All* | Total formula weight | 163002.7 |
