9WG4
Cryo-EM structure of pocket engineered OR52cs in its active state
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (N) | Nanobody 35 | polymer | 130 | 14273.9 | 1 | Lama glama | ||
| 2 | B (R) | Pocket engineered human consensus OR52 (OR52cs) | polymer | 323 | 36534.8 | 1 | Homo sapiens | ||
| 3 | C (X) | mini form Guanine nucleotide-binding protein G(s) subunit alpha | polymer | 248 | 28907.7 | 1 | Homo sapiens | ||
| 4 | D (Y) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) | Homo sapiens (human) | Transducin beta chain 1 |
| 5 | E (Z) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) | Homo sapiens (human) | G gamma-I |
| 6 | F (R) | (3~{R})-3-methyl-3-oxidanyl-hexanoic acid | non-polymer | 146.2 | 1 | Chemie (A1MBN) |
Sequence modifications
Y: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | initiating methionine |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 126995.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 146.2 | |
| All* | Total formula weight | 127141.8 |
