9WDP

Cyro-EM structure of prefusion RSV fusion glycoprotein in complex with Ziresovir and motavizumab Fab

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C (A, B, C)	Fusion glycoprotein F0,Fibritin	polymer	593	65513.7	3	UniProt (P03420) UniProt (P10104)	Human respiratory syncytial virus A2	Collar protein,Whisker antigen control protein
2	D, F, H (D, F, H)	Motavizumab Fab heavy chain	polymer	225	24284.5	3		Mus musculus
3	E, G, I (E, G, L)	Motavizumab Fab light chain	polymer	213	23104.6	3		Mus musculus
4	J (B)	~{N}-[(3-azanyloxetan-3-yl)methyl]-2-[1,1-bis(oxidanylidene)-3,5-dihydro-2~{H}-1$l^{6},4-benzothiazepin-4-yl]-6-methyl-quinazolin-4-amine	non-polymer		439.5	1	Chemie (A1EV1)

Sequence modifications

A, B, C: 1 - 513 (UniProt: P03420)

PDB	External Database	Details
Ala 102	Pro 102	variant
Cys 155	Ser 155	conflict
Phe 190	Ser 190	conflict
Leu 207	Val 207	conflict
Cys 290	Ser 290	conflict
Val 379	Ile 379	variant
Val 447	Met 447	variant
Gly 514	-	linker
Ser 515	-	linker

A, B, C: 516 - 543 (UniProt: P10104)

PDB	External Database	Details
Gly 544	-	expression tag
Leu 545	-	expression tag
Glu 546	-	expression tag
Val 547	-	expression tag
Leu 548	-	expression tag
Phe 549	-	expression tag
Gln 550	-	expression tag
Gly 551	-	expression tag
Pro 552	-	expression tag
Gly 553	-	expression tag
Gly 554	-	expression tag
Trp 555	-	expression tag
Ser 556	-	expression tag
His 557	-	expression tag
Pro 558	-	expression tag
Gln 559	-	expression tag
Phe 560	-	expression tag
Glu 561	-	expression tag
Lys 562	-	expression tag
Gly 563	-	expression tag
Gly 564	-	expression tag
Gly 565	-	expression tag
Ser 566	-	expression tag
Gly 567	-	expression tag
Gly 568	-	expression tag
Gly 569	-	expression tag
Ser 570	-	expression tag
Gly 571	-	expression tag
Gly 572	-	expression tag
Ser 573	-	expression tag
Ala 574	-	expression tag
Trp 575	-	expression tag
Ser 576	-	expression tag
His 577	-	expression tag
Pro 578	-	expression tag
Gln 579	-	expression tag
Phe 580	-	expression tag
Glu 581	-	expression tag
Lys 582	-	expression tag
Gly 583	-	expression tag
Gly 584	-	expression tag
Ser 585	-	expression tag
Gly 586	-	expression tag
Pro 587	-	expression tag
His 588	-	expression tag
His 589	-	expression tag
His 590	-	expression tag
His 591	-	expression tag
His 592	-	expression tag
His 593	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	338708.3
Non-Polymers*	Number of molecules	1
	Total formula weight	439.5
All*	Total formula weight	339147.8

*Water molecules are not included.