9WDH
Crystal Structure of CBL-B in Complex with a Potent Inhibitor Demonstrating In Vivo Efficacy
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase CBL-B | polymer | 394 | 45694.3 | 2 | UniProt (Q13191) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) Pfam (PF00097) | Homo sapiens (human) | Casitas B-lineage lymphoma proto-oncogene b,RING finger protein 56,RING-type E3 ubiquitin transferase CBL-B,SH3-binding protein CBL-B,Signal transduction protein CBL-B |
| 2 | C, G (A, B) | 5-fluoranyl-3-[3-[3-methyl-1-(4-methyl-1,2,4-triazol-3-yl)cyclobutyl]phenyl]-8-[[(3~{S})-3-methylpiperidin-1-yl]methyl]-1~{H}-quinolin-2-one | non-polymer | 499.6 | 2 | Chemie (A1EVY) | |||
| 3 | D, E, F, H, I (A, B) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) PubChem (32051) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 91388.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1326.3 | |
| All* | Total formula weight | 92715.0 |
