9WD3
Crystal structure of HPK1 kinase in complex with a potent and selective inhibitor with in vivo efficacy
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Mitogen-activated protein kinase kinase kinase kinase 1 | polymer | 299 | 33309.7 | 8 | UniProt (Q92918) Pfam (PF00069) | Homo sapiens (human) | Hematopoietic progenitor kinase,MAPK/ERK kinase kinase kinase 1,MEK kinase kinase 1,MEKKK 1 |
| 2 | I, J, K, L, M... (A, B, C, D, E...) | 5-(8-methoxyimidazo[1,2-a]pyridin-3-yl)-7,7-dimethyl-9-morpholin-4-yl-2,12-dihydrobenzo[b][1,9]phenanthrolin-1-one | non-polymer | 507.6 | 10 | Chemie (A1EVW) |
Sequence modifications
A, B, C, D, E, F, G, H: 2 - 298 (UniProt: Q92918)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Ala 171 | Ser 171 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 266477.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 5075.8 | |
| All* | Total formula weight | 271553.6 |
