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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9W2U

Cryo-EM structure of complex I on the bovine heart submitochondrial particles, open

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(J)		NADH-ubiquinone oxidoreductase chain 6polymer17519110.51UniProt (P03924)Bos taurus (domestic cattle)NADH dehydrogenase subunit 6
2B
(A)		NADH-ubiquinone oxidoreductase chain 3polymer11412927.31UniProt (Q8WAB4)Bos taurus (domestic cattle)NADH dehydrogenase subunit 3
3C
(B)		NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrialpolymer15517773.91UniProt (P42026)Bos taurus (domestic cattle)Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit,PSST subunit
4D
(C)		NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialpolymer20924547.71UniProt (P23709)Bos taurus (domestic cattle)Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit
5E
(D)		NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrialpolymer43049263.41UniProt (P17694)Bos taurus (domestic cattle)Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit
6F
(E)		NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrialpolymer21423655.21UniProt (P04394)Bos taurus (domestic cattle)NADH dehydrogenase subunit II,NADH-ubiquinone oxidoreductase 24 kDa subunit
7G
(F)		NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialpolymer43247383.91UniProt (P25708)Bos taurus (domestic cattle)NDUFV1,Complex I-51kD,CI-51kD,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit
8H
(G)		NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialpolymer69976628.61UniProt (P15690)Bos taurus (domestic cattle)Complex I-75kD,CI-75kD
9I
(H)		NADH-ubiquinone oxidoreductase chain 1polymer31735557.61UniProt (P03887)Bos taurus (domestic cattle)NADH dehydrogenase subunit 1
10J
(I)		NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrialpolymer17620219.91UniProt (P42028)Bos taurus (domestic cattle)Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit,TYKY subunit
11K
(K)		NADH-ubiquinone oxidoreductase chain 4Lpolymer9710669.01UniProt (Q6EMS3)Bos taurus (domestic cattle)NADH dehydrogenase subunit 4L
12L
(L)		NADH-ubiquinone oxidoreductase chain 5polymer60568196.71UniProt (P03920)Bos taurus (domestic cattle)NADH dehydrogenase subunit 5
13M
(M)		NADH-ubiquinone oxidoreductase chain 4polymer45851999.61UniProt (P03910)Bos taurus (domestic cattle)NADH dehydrogenase subunit 4
14N
(N)		NADH-ubiquinone oxidoreductase chain 2polymer34639143.71UniProt (P03892)Bos taurus (domestic cattle)NADH dehydrogenase subunit 2
15O
(O)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrialpolymer32036754.81UniProt (P34942)Bos taurus (domestic cattle)Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit
16P
(P)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrialpolymer34238932.81UniProt (P34943)Bos taurus (domestic cattle)Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit
17Q
(Q)		NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialpolymer12914918.91UniProt (Q02375)Bos taurus (domestic cattle)Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit
18R
(R)		NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrialpolymer9610551.71UniProt (P23934)Bos taurus (domestic cattle)Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit
19S
(S)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2polymer879970.51UniProt (Q02370)Bos taurus (domestic cattle)Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit
20T
(T)		Acyl carrier protein, mitochondrialpolymer859846.31UniProt (Q9CR21)Bos taurus (domestic cattle)ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit
21U
(U)		Acyl carrier protein, mitochondrialpolymer869917.41UniProt (P52505)Bos taurus (domestic cattle)ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit
22V
(V)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5polymer11513203.41UniProt (P23935)Bos taurus (domestic cattle)Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit
23W
(W)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6polymer11513884.11UniProt (Q02366)Bos taurus (domestic cattle)Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit
24X
(X)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8polymer17119992.91UniProt (P42029)Bos taurus (domestic cattle)Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit
25Y
(t)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11polymer14114666.91UniProt (Q8HXG6)Bos taurus (domestic cattle)Complex I-B14.7,CI-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7
26Z
(Z)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13polymer14116421.01UniProt (Q95KV7)Bos taurus (domestic cattle)Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit
27AA
(a)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1polymer708117.41UniProt (Q02377)Bos taurus (domestic cattle)Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit
28BA
(b)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3polymer839226.71UniProt (Q02371)Bos taurus (domestic cattle)Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit
29CA
(c)		NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrialpolymer495836.71UniProt (Q02376)Bos taurus (domestic cattle)Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit
30DA
(d)		NADH dehydrogenase [ubiquinone] 1 subunit C2polymer11913986.11UniProt (Q02827)Bos taurus (domestic cattle)Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b
31EA
(e)		NADH dehydrogenase [ubiquinone] iron-sulfur protein 5polymer9911835.71UniProt (Q02379)Bos taurus (domestic cattle)Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit
32FA
(f)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1polymer576978.11UniProt (Q02378)Bos taurus (domestic cattle)Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit
33GA
(g)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrialpolymer10011897.31UniProt (Q8HXG5)Bos taurus (domestic cattle)Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit
34HA
(h)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialpolymer13816297.91UniProt (Q02380)Bos taurus (domestic cattle)Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit
35IA
(u)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6polymer12815444.91UniProt (Q02367)Bos taurus (domestic cattle)Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit
36JA
(j)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialpolymer718385.21UniProt (Q02374)Bos taurus (domestic cattle)Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit
37KA
(k)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3polymer819229.51UniProt (Q02365)Bos taurus (domestic cattle)Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit
38LA
(l)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrialpolymer15618599.81UniProt (Q02372)Bos taurus (domestic cattle)Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit
39MA
(m)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4polymer12815075.11UniProt (P48305)Bos taurus (domestic cattle)Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit
40NA
(n)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9polymer17221134.11UniProt (Q02369)Bos taurus (domestic cattle)Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit
41OA
(o)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7polymer12214978.11UniProt (Q02368)Bos taurus (domestic cattle)Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit
42PA
(p)		NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10polymer17320701.51UniProt (Q02373)Bos taurus (domestic cattle)Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit
43QA
(q)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12polymer14517115.51UniProt (O97725)Bos taurus (domestic cattle)Complex I-B17.2,CIB17.2,NADH-ubiquinone oxidoreductase subunit B17.2
44RA
(v)		NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7polymer11312590.41UniProt (Q05752)Bos taurus (domestic cattle)Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a
45SA
(s)		NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrialpolymer455392.91UniProt (P56181)Bos taurus (domestic cattle)Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit,Renal carcinoma antigen NY-REN-4
46FB, LB, NB, TA, TB...
(H, K, L, A, M...)		N-FORMYLMETHIONINEnon-polymer177.26Chemie (FME)
PubChem (911)
PubChem (439750)
PubChem (6995182)
47HB, IB, KC, OC, RB...
(H, I, Z, d, L...)		1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINEnon-polymer790.111Chemie (PC1)
PubChem (65146)
PubChem (94190)
PubChem (10417837)
48AB, BB, CB, JB, KB...
(F, G, I, B)		IRON/SULFUR CLUSTERnon-polymer351.66Chemie (SF4)
49DB, YA
(G, E)		FE2/S2 (INORGANIC) CLUSTERnon-polymer175.82Chemie (FES)
50ZA
(F)		FLAVIN MONONUCLEOTIDEnon-polymer456.31Chemie (FMN)
PubChem (710)
PubChem (8965)
PubChem (23585816)
PubChem (643976)
PubChem (51435500)
PubChem (51435503)
PubChem (5702760)
PubChem (7048779)
PubChem (7048781)
PubChem (15559251)
51EB
(G)		POTASSIUM IONnon-polymer39.11Chemie (K)
PubChem (813)
52FC, GB, GC, HC, IC...
(t, H, b, K, d...)		1,2-Distearoyl-sn-glycerophosphoethanolaminenon-polymer748.118Chemie (3PE)
53AC, MC, PB, PC, QC...
(O, d, L, h, v)		CARDIOLIPINnon-polymer1464.06Chemie (CDL)
PubChem (17753886)
PubChem (5287898)
54SB
(L)		CHOLIC ACIDnon-polymer408.61Chemie (CHD)
PubChem (16401672)
PubChem (16758100)
PubChem (18528842)
PubChem (20638765)
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55BC
(O)		GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
PubChem (177679032)
PubChem (135400627)
PubChem (135487750)
PubChem (136088935)
PubChem (136803486)
PubChem (135398633)
PubChem (135544356)
PubChem (135547949)
PubChem (135600366)
PubChem (135749822)
PubChem (136005188)
PubChem (136073923)
PubChem (136240914)
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PubChem (136772743)
PubChem (136772744)
PubChem (136803487)
PubChem (137286749)
PubChem (164715984)
PubChem (171699466)
56CC
(O)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
PubChem (888)
57DC
(P)		NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATEnon-polymer745.41Chemie (NDP)
58EC
(R)		ZINC IONnon-polymer65.41Chemie (ZN)
59WC
(o)		MYRISTIC ACIDnon-polymer228.41Chemie (MYR)
PubChem (11005)
Sequence modifications
A: 2 - 115 (UniProt: Q8WAB4)
PDBExternal DatabaseDetails
Ala 82Thr 82conflict
D: 1 - 430 (UniProt: P17694)
PDBExternal DatabaseDetails
Arg 129Gln 162conflict
O: 1 - 320 (UniProt: P34942)
PDBExternal DatabaseDetails
Lys 255Asn 278conflict
T: 4 - 88 (UniProt: Q9CR21)
PDBExternal DatabaseDetails
Glu 9Asp 77conflict
t: 1 - 140 (UniProt: Q8HXG6)
PDBExternal DatabaseDetails
Ace 0-acetylation
u: 1 - 127 (UniProt: Q02367)
PDBExternal DatabaseDetails
Ace 0-acetylation
v: 1 - 112 (UniProt: Q05752)
PDBExternal DatabaseDetails
Ace 0-acetylation
s: 31 - 75 (UniProt: P56181)
PDBExternal DatabaseDetails
Asp 57Glu 90conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains45
Total formula weight948960.9
Non-Polymers*Number of molecules57
Total formula weight36956.5
All*Total formula weight985917.4
*Water molecules are not included.

251422

PDB entries from 2026-04-01

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