9W11
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with beta-zearalenol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 263 | 29701.0 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, E (A, B) | (3S,7S,11E)-7,14,16-trihydroxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1H-2-benzoxacyclotetradecin-1-one | non-polymer | 320.4 | 2 | Chemie (ZHB) PubChem (6437352) | |||
| 3 | D (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 4 | F, G (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | H (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A, B: 305 - 600 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Gly 300 | - | expression tag |
| Ala 301 | - | expression tag |
| Gly 302 | - | expression tag |
| Ala 303 | - | expression tag |
| Gly 304 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
| Ala 601 | - | expression tag |
| Ile 602 | - | expression tag |
| Leu 603 | - | expression tag |
| His 604 | - | expression tag |
| Arg 605 | - | expression tag |
| Leu 606 | - | expression tag |
| Leu 607 | - | expression tag |
| Gln 608 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59401.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1001.1 | |
| All* | Total formula weight | 60403.0 |
