9VXU
Cryo-EM structure of STING mutant complex with cGAMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Stimulator of interferon genes protein | polymer | 379 | 42213.4 | 4 | UniProt (Q86WV6) Pfam (PF23417) Pfam (PF15009) | Homo sapiens (human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
| 2 | E, F (B, C) | cGAMP | non-polymer | 674.4 | 2 | Chemie (1SY) |
Sequence modifications
A, B, C, D: 1 - 379 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Asn 150 | Lys 150 | engineered mutation |
| Ser 154 | Asn 154 | variant |
| Arg 232 | His 232 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 168853.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1348.8 | |
| All* | Total formula weight | 170202.5 |
