9VWF

Cryo-EM structure of RSV pre-F (strain A2) in complex with Fab 3G12

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G (A, B, C)	Fusion glycoprotein F0,Fibritin	polymer	570	63314.5	3	UniProt (P03420) UniProt (A0A346FJN8)	Respiratory syncytial virus A2	Phage neck whiskers protein
2	B, E, H (H, D, E)	3G12 heavy chain	polymer	122	13411.1	3		Homo sapiens
3	C, F, I (L, F, G)	3G12 light chain	polymer	111	11484.6	3		Homo sapiens

Sequence modifications

A, B, C: 1 - 513 (UniProt: P03420)

PDB	External Database	Details
Ala -1	-	expression tag
Thr 0	-	expression tag
Gly 46	Ser 46	conflict
Ile 67	Asn 67	conflict
Asp 92	Glu 92	conflict
Ala 102	Pro 102	conflict
Ser 144	Val 144	conflict
Cys 149	Ala 149	conflict
Cys 155	Ser 155	conflict
Phe 190	Ser 190	conflict
Leu 207	Val 207	conflict
Pro 215	Ser 215	conflict
Cys 290	Ser 290	conflict
Val 379	Ile 379	conflict
Val 447	Met 447	conflict
Cys 458	Tyr 458	conflict
Gln 465	Lys 465	conflict
Ser 514	-	linker
Ala 515	-	linker
Ile 516	-	linker
Gly 517	-	linker

A, B, C: 518 - 544 (UniProt: A0A346FJN8)

PDB	External Database	Details
Gly 545	-	expression tag
Gly 546	-	expression tag
Leu 547	-	expression tag
Val 548	-	expression tag
Pro 549	-	expression tag
Arg 550	-	expression tag
Gly 551	-	expression tag
Ser 552	-	expression tag
His 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag
His 556	-	expression tag
His 557	-	expression tag
His 558	-	expression tag
Ser 559	-	expression tag
Ala 560	-	expression tag
Trp 561	-	expression tag
Ser 562	-	expression tag
His 563	-	expression tag
Pro 564	-	expression tag
Gln 565	-	expression tag
Phe 566	-	expression tag
Glu 567	-	expression tag
Lys 568	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	264630.7
All*	Total formula weight	264630.7

*Water molecules are not included.