9VV1
Crystal structure of EGFR kinase (C797S) in complex with LN-B72
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 331 | 37557.4 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B (A) | (4-fluorophenyl)-[4-[[4-(hydroxymethyl)cyclohexyl]amino]-2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]-7~{H}-pyrrolo[2,3-d]pyrimidin-5-yl]methanone | non-polymer | 557.7 | 1 | Chemie (A1ETY) | |||
| 3 | C, D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | E (A) | water | water | 18.0 | 14 | Chemie (HOH) |
Sequence modifications
A: 694 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gln 692 | - | expression tag |
| Gly 693 | - | expression tag |
| Met 790 | Thr 790 | conflict |
| Ser 797 | Cys 797 | engineered mutation |
| Arg 858 | Leu 858 | conflict |
| Ala 865 | Glu 865 | conflict |
| Ala 866 | Glu 866 | conflict |
| Ala 867 | Lys 867 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37557.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 681.8 | |
| All* | Total formula weight | 38239.2 |
