9VUH

CDK11B ternary complex bound to AT7519

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cyclin-dependent kinase 11B	polymer	332	38171.0	1	UniProt (P21127)	Homo sapiens (human)	Cell division cycle 2-like protein kinase 1,CLK-1,Cell division protein kinase 11B,Galactosyltransferase-associated protein kinase p58/GTA,PITSLRE serine/threonine-protein kinase CDC2L1,p58 CLK-1
2	B (B)	Cyclin-L1	polymer	365	40238.1	1	UniProt (Q9UK58)	Homo sapiens (human)	Cyclin-L
3	C (C)	SAP30-binding protein	polymer	318	35056.5	1	UniProt (Q9UHR5)	Homo sapiens (human)	Transcriptional regulator protein HCNGP
4	D (A)	4-{[(2,6-dichlorophenyl)carbonyl]amino}-N-piperidin-4-yl-1H-pyrazole-3-carboxamide	non-polymer		382.2	1	Chemie (LZE)

Sequence modifications

A: 428 - 736 (UniProt: P21127)

PDB	External Database	Details
Met 411	-	initiating methionine
Ala 412	-	expression tag
Asp 413	-	expression tag
Tyr 414	-	expression tag
Lys 415	-	expression tag
Asp 416	-	expression tag
Asp 417	-	expression tag
Asp 418	-	expression tag
Asp 419	-	expression tag
Lys 420	-	expression tag
Ser 421	-	expression tag
Gly 422	-	expression tag
Arg 423	-	expression tag
Gly 424	-	expression tag
Ala 425	-	expression tag
Met 426	-	expression tag
Gly 427	-	expression tag
Lys 737	-	expression tag
Leu 738	-	expression tag
Val 739	-	expression tag
Glu 740	-	expression tag
Lys 741	-	expression tag
Tyr 742	-	expression tag

B: 1 - 329 (UniProt: Q9UK58)

PDB	External Database	Details
Arg 325	-	insertion
Ile 326	Thr 325	conflict
Gly 328	Ala 327	conflict
Ile 330	-	expression tag
Trp 331	-	expression tag
Ser 332	-	expression tag
His 333	-	expression tag
Pro 334	-	expression tag
Gln 335	-	expression tag
Phe 336	-	expression tag
Glu 337	-	expression tag
Lys 338	-	expression tag
Gly 339	-	expression tag
Gly 340	-	expression tag
Gly 341	-	expression tag
Ser 342	-	expression tag
Gly 343	-	expression tag
Gly 344	-	expression tag
Gly 345	-	expression tag
Gly 346	-	expression tag
Gly 347	-	expression tag
Ser 348	-	expression tag
Gly 349	-	expression tag
Gly 350	-	expression tag
Gly 351	-	expression tag
Ser 352	-	expression tag
Gly 353	-	expression tag
Gly 354	-	expression tag
Ser 355	-	expression tag
Ser 356	-	expression tag
Ala 357	-	expression tag
Trp 358	-	expression tag
Ser 359	-	expression tag
His 360	-	expression tag
Pro 361	-	expression tag
Gln 362	-	expression tag
Phe 363	-	expression tag
Glu 364	-	expression tag
Lys 365	-	expression tag

C: 1 - 308 (UniProt: Q9UHR5)

PDB	External Database	Details
Met -9	-	initiating methionine
Gly -8	-	expression tag
Ser -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag
Thr 34	Ala 34	conflict
Asn 305	Lys 305	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	113465.7
Non-Polymers*	Number of molecules	1
	Total formula weight	382.2
All*	Total formula weight	113848.0

*Water molecules are not included.