9VUG
Structure of human proteasome ATPase-CP intermediate assembles with 90min rapaprotin addition
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 26S proteasome regulatory subunit 7 | polymer | 433 | 48700.8 | 1 | UniProt (P35998) Pfam (PF21236) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT1,Proteasome 26S subunit ATPase 2 |
| 2 | B (B) | 26S proteasome regulatory subunit 4 | polymer | 440 | 49260.5 | 1 | UniProt (P62191) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (human) | P26s4,26S proteasome AAA-ATPase subunit RPT2,Proteasome 26S subunit ATPase 1 |
| 3 | C (C) | 26S proteasome regulatory subunit 8 | polymer | 406 | 45694.0 | 1 | UniProt (P62195) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT6,Proteasome 26S subunit ATPase 5,Proteasome subunit p45,Thyroid hormone receptor-interacting protein 1,TRIP1,p45/SUG |
| 4 | D (D) | 26S proteasome regulatory subunit 6B | polymer | 418 | 47426.1 | 1 | UniProt (P43686) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT3,MB67-interacting protein,MIP224,Proteasome 26S subunit ATPase 4,Tat-binding protein 7,TBP-7 |
| 5 | E (E) | 26S proteasome regulatory subunit 10B | polymer | 389 | 44241.0 | 1 | UniProt (P62333) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT4,Proteasome 26S subunit ATPase 6,Proteasome subunit p42 |
| 6 | F (F) | 26S proteasome regulatory subunit 6A | polymer | 439 | 49266.5 | 1 | UniProt (P17980) Pfam (PF16450) Pfam (PF00004) Pfam (PF17862) | Homo sapiens (human) | 26S proteasome AAA-ATPase subunit RPT5,Proteasome 26S subunit ATPase 3,Proteasome subunit P50,Tat-binding protein 1,TBP-1 |
| 7 | G, V (G, g) | Proteasome subunit alpha type-6 | polymer | 246 | 27432.5 | 2 | UniProt (P60900) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | 27 kDa prosomal protein,PROS-27,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain,Proteasome subunit alpha-1,alpha-1 |
| 8 | H, W (H, h) | Proteasome subunit alpha type-2 | polymer | 234 | 25927.5 | 2 | UniProt (P25787) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3,Proteasome subunit alpha-2,alpha-2 |
| 9 | I, X (I, i) | Proteasome subunit alpha type-4 | polymer | 261 | 29525.8 | 2 | UniProt (P25789) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L,Proteasome subunit alpha-3,alpha-3 |
| 10 | J, Y (J, j) | Proteasome subunit alpha type-7 | polymer | 248 | 27929.9 | 2 | UniProt (O14818) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Proteasome subunit RC6-1,Proteasome subunit XAPC7,Proteasome subunit alpha-4,alpha-4 |
| 11 | K, Z (K, k) | Proteasome subunit alpha type-5 | polymer | 241 | 26436.0 | 2 | UniProt (P28066) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome subunit alpha-5,alpha-5,Proteasome zeta chain |
| 12 | AA, L (L, l) | Isoform Long of Proteasome subunit alpha type-1 | polymer | 269 | 30281.5 | 2 | UniProt (P25786) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Proteasome subunit alpha type-1,30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain,Proteasome subunit alpha-6,alpha-6 |
| 13 | BA, M (M, m) | Proteasome subunit alpha type-3 | polymer | 255 | 28469.3 | 2 | UniProt (P25788) Pfam (PF10584) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8,Proteasome subunit alpha-7,alpha-7 |
| 14 | CA, N (N, n) | Proteasome subunit beta type-6 | polymer | 239 | 25377.7 | 2 | UniProt (P28072) Pfam (PF00227) | Homo sapiens (human) | Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y,Proteasome subunit beta-1,beta-1 |
| 15 | DA, O (O, o) | Proteasome subunit beta type-7 | polymer | 277 | 30000.4 | 2 | UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) | Homo sapiens (human) | Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z,Proteasome subunit beta-2,beta-2 |
| 16 | EA, P (P, p) | Proteasome subunit beta type-3 | polymer | 205 | 22972.9 | 2 | UniProt (P49720) Pfam (PF00227) | Homo sapiens (human) | Proteasome chain 13,Proteasome component C10-II,Proteasome subunit beta-3,beta-3,Proteasome theta chain |
| 17 | FA, Q (Q, q) | Proteasome subunit beta type-2 | polymer | 201 | 22864.3 | 2 | UniProt (P49721) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I,Proteasome subunit beta-4,beta-4 |
| 18 | GA, R (R, r) | Proteasome subunit beta type-5 | polymer | 263 | 28510.2 | 2 | UniProt (P28074) Pfam (PF00227) | Homo sapiens (human) | Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X,Proteasome subunit beta-5,beta-5 |
| 19 | HA, S (S, s) | Proteasome subunit beta type-1 | polymer | 241 | 26522.4 | 2 | UniProt (P20618) Pfam (PF00227) | Homo sapiens (human) | Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain,Proteasome subunit beta-6,beta-6 |
| 20 | IA, T (T, t) | Proteasome subunit beta type-4 | polymer | 264 | 29231.2 | 2 | UniProt (P28070) Pfam (PF00227) | Homo sapiens (human) | 26 kDa prosomal protein,HsBPROS26,PROS-26,Macropain beta chain,Multicatalytic endopeptidase complex beta chain,Proteasome beta chain,Proteasome chain 3,HsN3,Proteasome subunit beta-7,beta-7 |
| 21 | U (f) | 26S proteasome non-ATPase regulatory subunit 2 | polymer | 908 | 100313.6 | 1 | UniProt (Q13200) Pfam (PF17781) Pfam (PF01851) Pfam (PF18051) | Homo sapiens (human) | 26S proteasome regulatory subunit RPN1,26S proteasome regulatory subunit S2,26S proteasome subunit p97,Protein 55.11,Tumor necrosis factor type 1 receptor-associated protein 2 |
| 22 | JA, KA, LA, NA (A, C, D, F) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 4 | Chemie (ATP) | |||
| 23 | MA (D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 35 |
| Total formula weight | 1147865.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2455.9 | |
| All* | Total formula weight | 1150321.5 |
