9VTU
Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Compound 20a and GRIP Peptide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, A) | Estrogen receptor | polymer | 261 | 29572.8 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER,ER-alpha,Estradiol receptor,Nuclear receptor subfamily 3 group A member 1 |
| 2 | C (A) | N-(1-adamantyl)-2-[4-[[(1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-en-2-yl]sulfonyl-[2,2,2-tris(fluoranyl)ethyl]amino]phenoxy]ethanamide | non-polymer | 724.8 | 1 | Chemie (A1ETN) | |||
| 3 | D, E (B, A) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
B, A: 305 - 600 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Gly 302 | - | expression tag |
| Ala 303 | - | expression tag |
| Gly 304 | - | expression tag |
| Ser 537 | Tyr 537 | engineered mutation |
| Ala 601 | - | expression tag |
| Ile 602 | - | expression tag |
| Leu 603 | - | expression tag |
| His 604 | - | expression tag |
| Arg 605 | - | expression tag |
| Leu 606 | - | expression tag |
| Leu 607 | - | expression tag |
| Gln 608 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59145.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 724.8 | |
| All* | Total formula weight | 59870.4 |
