9VSL
Cryo-EM structrure of a human flippase mutant ATP11C Q79E-CDC50A in PtdCho-open E2-BeF state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Phospholipid-transporting ATPase IG | polymer | 1082 | 124165.3 | 1 | UniProt (Q8NB49) Pfam (PF16209) Pfam (PF00122) Pfam (PF13246) Pfam (PF16212) | Homo sapiens (human) | ATPase IQ,ATPase class VI type 11C,P4-ATPase flippase complex alpha subunit ATP11C |
| 2 | B (C) | Cell cycle control protein 50A | polymer | 361 | 40900.8 | 1 | UniProt (Q9NV96) Pfam (PF03381) | Homo sapiens (human) | P4-ATPase flippase complex beta subunit TMEM30A,Transmembrane protein 30A |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 1 | Chemie (PCW) | |||
| 5 | E, F, G, H (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) |
Sequence modifications
A: 10 - 1091 (UniProt: Q8NB49)
C: 1 - 361 (UniProt: Q9NV96)
| PDB | External Database | Details |
|---|---|---|
| Glu 79 | Gln 82 | engineered mutation |
| Trp 111 | Cys 114 | variant |
| PDB | External Database | Details |
|---|---|---|
| Met 175 | Ala 175 | variant |
| Gln 190 | Asn 190 | variant |
| Trp 292 | Ser 292 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 165066.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1696.3 | |
| All* | Total formula weight | 166762.3 |
