9VS9

Small molecule 3-127 targeting YTHDC1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	YTH domain-containing protein 1	polymer	187	21197.5	2	UniProt (Q96MU7)	Homo sapiens (human)	Splicing factor YT521,YT521-B
2	C (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	D, E (A, B)	2-chloranyl-~{N}-methyl-9~{H}-purin-6-amine	non-polymer		183.6	2	Chemie (OYN)
4	F, G (A, B)	water	water		18.0	128	Chemie (HOH)

Sequence modifications

A, B: 344 - 509 (UniProt: Q96MU7)

PDB	External Database	Details
Met 323	-	initiating methionine
Gly 324	-	expression tag
Ser 325	-	expression tag
Ser 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
Ser 333	-	expression tag
Ser 334	-	expression tag
Gly 335	-	expression tag
Leu 336	-	expression tag
Val 337	-	expression tag
Pro 338	-	expression tag
Arg 339	-	expression tag
Gly 340	-	expression tag
Ser 341	-	expression tag
His 342	-	expression tag
Met 343	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	42394.9
Non-Polymers*	Number of molecules	3
	Total formula weight	463.3
All*	Total formula weight	42858.2

*Water molecules are not included.