9VQ0
Crystal structure of wild-type Trypanosoma brucei DHODH in FMN-oxidized, orotate-bound form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dihydroorotate dehydrogenase (fumarate) | polymer | 317 | 34473.7 | 4 | UniProt (Q57U83) Pfam (PF01180) | Trypanosoma brucei brucei TREU927 | DHOD,DHODase,DHOdehase,Dihydroorotate oxidase |
| 2 | E, I, N, Q (A, B, C, D) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 4 | Chemie (FMN) | |||
| 3 | F, J, O, R (A, B, C, D) | OROTIC ACID | non-polymer | 156.1 | 4 | Chemie (ORO) | |||
| 4 | G, H, K, L, M... (A, B, C, D) | MALONATE ION | non-polymer | 102.0 | 7 | Chemie (MLI) | |||
| 5 | T, U, V, W (A, B, C, D) | water | water | 18.0 | 380 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 313 (UniProt: Q57U83)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Val 115 | Ala 115 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 137894.6 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3164.1 | |
| All* | Total formula weight | 141058.7 |
