9VPZ
Crystal structure of wild-type Trypanosoma brucei DHODH in FMN-reduced, ligand-free form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, C, B, D) | Dihydroorotate dehydrogenase (fumarate) | polymer | 317 | 34473.7 | 4 | UniProt (Q57U83) Pfam (PF01180) | Trypanosoma brucei brucei TREU927 | DHOD,DHODase,DHOdehase,Dihydroorotate oxidase |
| 2 | E, J, Q, X (A, C, B, D) | 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL | non-polymer | 458.4 | 4 | Chemie (FNR) | |||
| 3 | F, G, K, L, M... (A, C, B, D) | MALONATE ION | non-polymer | 102.0 | 11 | Chemie (MLI) | |||
| 4 | H, O, V, Z (A, C, B, D) | SULFUR DIOXIDE | non-polymer | 64.1 | 4 | Chemie (SO2) | |||
| 5 | AA, I, P, W (D, A, C, B) | SULFITE ION | non-polymer | 80.1 | 4 | Chemie (SO3) | |||
| 6 | BA, CA, DA, EA (A, C, B, D) | water | water | 18.0 | 432 | Chemie (HOH) |
Sequence modifications
A, C, B, D: 1 - 313 (UniProt: Q57U83)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Val 115 | Ala 115 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 137894.6 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 3532.5 | |
| All* | Total formula weight | 141427.1 |
