9VPT
Crystal structure of the C131A mutant of Trypanosoma brucei DHODH in FMN-oxidized, dihydroorotate-bound form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dihydroorotate dehydrogenase (fumarate) | polymer | 317 | 34441.6 | 4 | UniProt (Q57U83) Pfam (PF01180) | Trypanosoma brucei brucei TREU927 | DHOD,DHODase,DHOdehase,Dihydroorotate oxidase |
| 2 | E, K, P, V (A, B, C, D) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 4 | Chemie (FMN) PubChem (710) PubChem (23585816) PubChem (8965) PubChem (51435500) PubChem (51435503) PubChem (643976) PubChem (5702760) PubChem (7048779) PubChem (7048781) PubChem (15559251) | |||
| 3 | F, L, Q, W (A, B, C, D) | (4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID | non-polymer | 158.1 | 4 | Chemie (DOR) PubChem (648) PubChem (439216) PubChem (1149667) | |||
| 4 | G, H, I, J, M... (A, B, C, D) | MALONATE ION | non-polymer | 102.0 | 14 | Chemie (MLI) PubChem (9084) | |||
| 5 | AA, BA, CA, DA (A, B, C, D) | water | water | 18.0 | 683 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 313 (UniProt: Q57U83)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Val 115 | Ala 115 | engineered mutation |
| Ala 131 | Cys 131 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 137766.4 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 3886.5 | |
| All* | Total formula weight | 141652.8 |
