9VPQ
Crystal structure of METTL9 in complex with compound 15k
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Protein-L-histidine N-pros-methyltransferase | polymer | 274 | 31371.7 | 2 | UniProt (Q9H1A3) Pfam (PF05219) | Homo sapiens (human) | DORA reverse strand protein,DREV,DREV1,Methyltransferase-like protein 9,hMETTL9 |
| 2 | B, D (C, D) | Zinc transporter ZIP5 | polymer | 12 | 1199.2 | 2 | UniProt (Q6ZMH5) | Homo sapiens | Solute carrier family 39 member 5,Zrt- and Irt-like protein 5,ZIP-5 |
| 3 | E, F (A, B) | ~{N}-[2-fluoranyl-5-[8-fluoranyl-4-[(3-hydroxyphenyl)amino]quinazolin-6-yl]pyridin-3-yl]benzenesulfonamide | non-polymer | 505.5 | 2 | Chemie (A1ES7) | |||
| 4 | G, H, I (A, C, B) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A, B: 46 - 318 (UniProt: Q9H1A3)
| PDB | External Database | Details |
|---|---|---|
| Ser 45 | - | expression tag |
| Ala 95 | Leu 95 | engineered mutation |
| Ala 96 | Phe 96 | engineered mutation |
| Ala 99 | Leu 99 | engineered mutation |
| Ala 103 | Phe 103 | engineered mutation |
| Ala 107 | Val 107 | engineered mutation |
| Ala 111 | Phe 111 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 65141.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1011.0 | |
| All* | Total formula weight | 66152.9 |
