9VP0

Structural insights into IL-31 signaling inhibition by a neutralization antibody

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin 31	polymer	144	16506.9	1	UniProt (C7G0W1) Pfam (PF15209)	Canis lupus familiaris (dog)
2	B (H)	Antibody-H	polymer	217	23392.3	1		Canis lupus familiaris
3	C (L)	Antibody-L	polymer	222	24779.6	1		Canis lupus familiaris
4	D, E, F (A, H, L)	water	water		18.0	270	Chemie (HOH)

Sequence modifications

A: 2 - 136 (UniProt: C7G0W1)

PDB	External Database	Details
Met 1	-	initiating methionine
Leu 137	-	expression tag
Glu 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
His 141	-	expression tag
His 142	-	expression tag
His 143	-	expression tag
His 144	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	64678.8
All*	Total formula weight	64678.8

*Water molecules are not included.