9VLQ

herpes simplex virus type 1 helicase-primase structure in complex with ssDNA, ADP and magnesium ion

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA replication helicase	polymer	907	101903.5	1	UniProt (P10189)	Human alphaherpesvirus 1 strain 17
2	B (B)	Helicase-primase subunit	polymer	775	83086.0	1	UniProt (G8HBC1)	Human alphaherpesvirus 1 strain 17
3	C (C)	DNA primase	polymer	1058	114558.6	1	UniProt (P10236)	Human alphaherpesvirus 1 strain 17
4	D (X)	DNA (44-MER)	polymer	44	13402.6	1		ssDNA virus sp.
5	E (A)	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
6	F (A)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

A: 1 - 882 (UniProt: P10189)

PDB	External Database	Details
Met -24	-	initiating methionine
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
Asp -15	-	expression tag
Tyr -14	-	expression tag
Asp -13	-	expression tag
Ile -12	-	expression tag
Pro -11	-	expression tag
Thr -10	-	expression tag
Thr -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Ala -1	-	expression tag
Asp 0	-	expression tag

B: 1 - 750 (UniProt: G8HBC1)

PDB	External Database	Details
Met -24	-	initiating methionine
His -23	-	expression tag
His -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
Asp -15	-	expression tag
Tyr -14	-	expression tag
Asp -13	-	expression tag
Ile -12	-	expression tag
Pro -11	-	expression tag
Thr -10	-	expression tag
Thr -9	-	expression tag
Glu -8	-	expression tag
Asn -7	-	expression tag
Leu -6	-	expression tag
Tyr -5	-	expression tag
Phe -4	-	expression tag
Gln -3	-	expression tag
Gly -2	-	expression tag
Ala -1	-	expression tag
Asp 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	312950.6
Non-Polymers*	Number of molecules	2
	Total formula weight	451.5
All*	Total formula weight	313402.1

*Water molecules are not included.