9VLJ
Crystal structure of FGFR1 in complex with covalent inhibitor 10a
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 1 | polymer | 310 | 35264.5 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (human) | FGFR-1,Basic fibroblast growth factor receptor 1,BFGFR,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 2 | C, J (A, B) | ~{N}-[3-[2-[[3-[2-(dimethylamino)ethylsulfamoylmethyl]phenyl]amino]pyrimidin-4-yl]-1-methyl-indol-6-yl]propanamide | non-polymer | 535.7 | 2 | Chemie (A1ESP) | |||
| 3 | D, E, F, G, H... (A, B) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 4 | O, P (A, B) | water | water | 18.0 | 423 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 456 | - | expression tag |
| Pro 457 | - | expression tag |
| Ser 584 | Cys 584 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70529.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2032.0 | |
| All* | Total formula weight | 72561.0 |
