9VLG

Structure of human alpha-2/delta-1 with crisugabalin

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Isoform 2 of Voltage-dependent calcium channel subunit alpha-2/delta-1	polymer	1064	120990.8	1	UniProt (P54289) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473)	Homo sapiens (human)	Voltage-gated calcium channel subunit alpha-2/delta-1
2	B, C, E (B, C, E)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)
3	D (D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	F, G (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	H (A)	Crisugabalin	non-polymer		209.3	1	Chemie (A1ESQ)

Sequence modifications

A: 25 - 1064 (UniProt: P54289)

PDB	External Database	Details
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
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His 16	-	expression tag
Trp 17	-	expression tag
Ser 18	-	expression tag
His 19	-	expression tag
Pro 20	-	expression tag
Gln 21	-	expression tag
Phe 22	-	expression tag
Glu 23	-	expression tag
Lys 24	-	expression tag
His 677	-	insertion
His 677	-	insertion
His 677	-	insertion
His 677	-	insertion
His 677	-	insertion
His 677	-	insertion
His 677	-	insertion
His 677	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	120990.8
Branched	Number of molecules	4
	Total formula weight	2184.0
Non-Polymers*	Number of molecules	3
	Total formula weight	651.7
All*	Total formula weight	123826.5

*Water molecules are not included.