9VJR

Cryo-EM structure of TRP melastatin channel with icilin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, C, B, D)	Transient receptor potential cation channel subfamily M member 8	polymer	1118	129402.1	4	UniProt (Q8R4D5)	Mus musculus (house mouse)	Long transient receptor potential channel 6,LTrpC-6,LTrpC6,Transient receptor potential p8,Trp-p8
2	E, I, M, Q (A, C, B, D)	[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate	non-polymer		746.6	4	Chemie (PIO)
3	F, J, N, R (A, C, B, D)	CALCIUM ION	non-polymer		40.1	4	Chemie (CA) PubChem (271)
4	G, K, O, S (A, C, B, D)	Icilin	non-polymer		311.3	4	Chemie (KX7) PubChem (161930)
5	H, L, P, T (A, C, B, D)	CHOLESTEROL	non-polymer		386.7	4	Chemie (CLR) PubChem (5997)

Sequence modifications

A, C, B, D: 2 - 1104 (UniProt: Q8R4D5)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Ala -3	-	expression tag
Arg -2	-	expression tag
Gly -1	-	expression tag
Ile 0	-	expression tag
Gln 1	-	expression tag
Asp 1105	-	expression tag
Tyr 1106	-	expression tag
Lys 1107	-	expression tag
Asp 1108	-	expression tag
Asp 1109	-	expression tag
Asp 1110	-	expression tag
Asp 1111	-	expression tag
Lys 1112	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	517608.2
Non-Polymers*	Number of molecules	16
	Total formula weight	5938.4
All*	Total formula weight	523546.6

*Water molecules are not included.