9VJQ
Cryo-EM structure of TRP melastatin channel with menthol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, D, B, C) | Transient receptor potential cation channel subfamily M member 8 | polymer | 1118 | 129402.1 | 4 | UniProt (Q8R4D5) | Mus musculus (house mouse) | Long transient receptor potential channel 6,LTrpC-6,LTrpC6,Transient receptor potential p8,Trp-p8 |
| 2 | E, H, K, N (A, D, B, C) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 4 | Chemie (PIO) | |||
| 3 | F, I, L, O (A, D, B, C) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) PubChem (271) | |||
| 4 | G, J, M, P (A, D, B, C) | (1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexan-1-ol | non-polymer | 156.3 | 4 | Chemie (XUQ) PubChem (16666) |
Sequence modifications
A, D, B, C: 2 - 1104 (UniProt: Q8R4D5)
| PDB | External Database | Details |
|---|---|---|
| Gly -5 | - | expression tag |
| Pro -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Arg -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ile 0 | - | expression tag |
| Gln 1 | - | expression tag |
| Asp 1105 | - | expression tag |
| Tyr 1106 | - | expression tag |
| Lys 1107 | - | expression tag |
| Asp 1108 | - | expression tag |
| Asp 1109 | - | expression tag |
| Asp 1110 | - | expression tag |
| Asp 1111 | - | expression tag |
| Lys 1112 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 517608.2 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3771.6 | |
| All* | Total formula weight | 521379.9 |
