9VJG
Cryo-EM structure of 5-HT1AR-Gz in complex with (R)-8-OH-DPAT
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Guanine nucleotide-binding protein G(z) subunit alpha | polymer | 355 | 40613.4 | 1 | Homo sapiens | ||
| 2 | B (C) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | |
| 3 | C (D) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 4 | D (E) | ScFv16 | polymer | 251 | 26679.7 | 1 | Mus musculus | ||
| 5 | E (R) | Soluble cytochrome b562,5-hydroxytryptamine receptor 1A | polymer | 549 | 60921.2 | 1 | UniProt (P0ABE7) UniProt (P08908) Pfam (PF00001) | Escherichia coli | Cytochrome b-562,5-HT-1A,5-HT1A,G-21,Serotonin receptor 1A |
| 6 | F, G (R) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (45044259) PubChem (49853509) PubChem (50990013) PubChem (176980071) PubChem (18640088) PubChem (52934537) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (44654663) PubChem (46937002) PubChem (56621683) PubChem (59274407) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (1551269) PubChem (90070115) PubChem (59450329) PubChem (59628412) PubChem (117965027) PubChem (6432564) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (132837164) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (304) PubChem (138967089) PubChem (139566851) PubChem (89951918) PubChem (90224410) PubChem (15939944) PubChem (91298236) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (638019) PubChem (101624109) PubChem (1549081) PubChem (1553803) PubChem (171828367) PubChem (173516975) PubChem (124225449) PubChem (124429284) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (6419195) PubChem (6994560) PubChem (130459183) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (131992107) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (139568882) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 7 | H (R) | (2R)-1-(heptadecanoyloxy)-3-{[(R)-hydroxy{[(1R,2R,3R,4R,5S,6R)-2,3,5,6-tetrahydroxy-4-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate | non-polymer | 953.1 | 1 | Chemie (T7M) PubChem (9547150) PubChem (137350036) PubChem (156963608) | |||
| 8 | I (R) | (7~{R})-7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol | non-polymer | 247.4 | 1 | Chemie (A1ESE) PubChem (1220) PubChem (6603866) PubChem (10125797) |
Sequence modifications
C: 2 - 340 (UniProt: P62873)
R: -85 - 12 (UniProt: P0ABE7)
R: 25 - 422 (UniProt: P08908)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | initiating methionine |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Asp -126 | - | expression tag |
| Tyr -125 | - | expression tag |
| Lys -124 | - | expression tag |
| Asp -123 | - | expression tag |
| Asp -122 | - | expression tag |
| Asp -121 | - | expression tag |
| Asp -120 | - | expression tag |
| Ala -119 | - | expression tag |
| Lys -118 | - | expression tag |
| Leu -117 | - | expression tag |
| Gln -116 | - | expression tag |
| Thr -115 | - | expression tag |
| Met -114 | - | expression tag |
| His -113 | - | expression tag |
| His -112 | - | expression tag |
| His -111 | - | expression tag |
| His -110 | - | expression tag |
| His -109 | - | expression tag |
| His -108 | - | expression tag |
| His -107 | - | expression tag |
| His -106 | - | expression tag |
| His -105 | - | expression tag |
| His -104 | - | expression tag |
| Glu -103 | - | expression tag |
| Asn -102 | - | expression tag |
| Leu -101 | - | expression tag |
| Tyr -100 | - | expression tag |
| Phe -99 | - | expression tag |
| Gln -98 | - | expression tag |
| Gly -97 | - | expression tag |
| Gly -96 | - | expression tag |
| Thr -95 | - | expression tag |
| Thr -94 | - | expression tag |
| Met -93 | - | expression tag |
| Ala -92 | - | expression tag |
| Asp -91 | - | expression tag |
| Leu -90 | - | expression tag |
| Glu -89 | - | expression tag |
| Asp -88 | - | expression tag |
| Asn -87 | - | expression tag |
| Trp -86 | - | expression tag |
| Ile 9 | His 124 | conflict |
| Leu 13 | - | linker |
| Gly 14 | - | linker |
| Ser 15 | - | linker |
| Thr 16 | - | linker |
| Leu 17 | - | linker |
| Glu 18 | - | linker |
| Val 19 | - | linker |
| Leu 20 | - | linker |
| Phe 21 | - | linker |
| Gln 22 | - | linker |
| Gly 23 | - | linker |
| Pro 24 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Trp 125 | Leu 125 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 175493.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1973.8 | |
| All* | Total formula weight | 177467.3 |
