9VGZ
SIRT2-F96A structure in complex with H3K18myr peptide and native NAD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacetylase sirtuin-2 | polymer | 307 | 34615.9 | 1 | UniProt (Q8IXJ6) Pfam (PF02146) | Homo sapiens (human) | NAD-dependent protein defatty-acylase sirtuin-2,Regulatory protein SIR2 homolog 2,SIR2-like protein 2 |
| 2 | B (C) | Histone H3.1 | polymer | 7 | 784.9 | 1 | UniProt (P68431) | Homo sapiens | Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l |
| 3 | C (A) | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | F (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 7 | G (C) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 8 | H (A) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A: 50 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| Ala 96 | Phe 96 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35400.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1125.4 | |
| All* | Total formula weight | 36526.2 |
