9VEI
structure of human KCNQ1-KCNE1-CaM complex with PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, J, K, L (A, D, G, J) | Potassium voltage-gated channel subfamily KQT member 1 | polymer | 546 | 62076.3 | 4 | UniProt (P51787) Pfam (PF00520) Pfam (PF07885) Pfam (PF03520) | Homo sapiens (human) | IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1,KQT-like 1,Voltage-gated potassium channel subunit Kv7.1 |
| 2 | B, D, E, F (B, E, H, K) | Calmodulin-1 | polymer | 149 | 16852.5 | 4 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 3 | C, G, H, I (C, L, F, I) | Potassium voltage-gated channel subfamily E member 1 | polymer | 129 | 14664.7 | 4 | UniProt (P15382) Pfam (PF02060) | Homo sapiens (human) | Delayed rectifier potassium channel subunit IsK,IKs producing slow voltage-gated potassium channel subunit beta Mink,Minimal potassium channel,MinK |
| 4 | AA, BA, M, P, W... (G, J, A, C, L...) | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 8 | Chemie (PT5) | |||
| 5 | N, O, Q, R, S... (B, E, H, K) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) |
Sequence modifications
A, D, G, J: 76 - 620 (UniProt: P51787)
C, L, F, I: 1 - 129 (UniProt: P15382)
| PDB | External Database | Details |
|---|---|---|
| Met 75 | - | initiating methionine |
| Cys 145 | Ile 145 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 41 | Lys 41 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 374374.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 8697.3 | |
| All* | Total formula weight | 383071.3 |
