9VEI
structure of human KCNQ1-KCNE1-CaM complex with PIP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, J, K, L (A, D, G, J) | Potassium voltage-gated channel subfamily KQT member 1 | polymer | 546 | 62076.3 | 4 | UniProt (P51787) Pfam (PF00520) Pfam (PF03520) | Homo sapiens (human) | IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1,KQT-like 1,Voltage-gated potassium channel subunit Kv7.1 |
| 2 | B, D, E, F (B, E, H, K) | Calmodulin-1 | polymer | 149 | 16852.5 | 4 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 3 | C, G, H, I (C, L, F, I) | Potassium voltage-gated channel subfamily E member 1 | polymer | 129 | 14664.7 | 4 | UniProt (P15382) Pfam (PF02060) | Homo sapiens (human) | Delayed rectifier potassium channel subunit IsK,IKs producing slow voltage-gated potassium channel subunit beta Mink,Minimal potassium channel,MinK |
| 4 | AA, BA, M, P, W... (G, J, A, C, L...) | [(2R)-1-octadecanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8Z)-icosa-5,8,11,14-tetraenoate | non-polymer | 1047.1 | 8 | Chemie (PT5) PubChem (21584053) PubChem (24742075) PubChem (25021172) PubChem (49867532) PubChem (53731018) PubChem (74343116) PubChem (46891800) PubChem (644093) PubChem (88368868) PubChem (101127471) PubChem (53480261) PubChem (137349554) PubChem (146672970) PubChem (162802760) PubChem (177693253) PubChem (101103400) PubChem (5497157) PubChem (137349667) PubChem (155387720) | |||
| 5 | N, O, Q, R, S... (B, E, H, K) | CALCIUM ION | non-polymer | 40.1 | 8 | Chemie (CA) PubChem (271) |
Sequence modifications
A, D, G, J: 76 - 620 (UniProt: P51787)
C, L, F, I: 1 - 129 (UniProt: P15382)
| PDB | External Database | Details |
|---|---|---|
| Met 75 | - | initiating methionine |
| Cys 145 | Ile 145 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 41 | Lys 41 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 374374.0 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 8697.3 | |
| All* | Total formula weight | 383071.3 |
