9V9X
Cryo-EM structure of the ncPRC1.4 complex containing one RNF2-BMI1 bound to the H2AK119ub-modified nucleosome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E (A, E) | Histone H3 | polymer | 136 | 15435.1 | 2 | UniProt (A0A310TTQ1) | Xenopus laevis (African clawed frog) | |
| 2 | B, F (B, F) | Histone H4 | polymer | 103 | 11394.4 | 2 | UniProt (P62799) | Xenopus laevis (African clawed frog) | |
| 3 | C, G (C, G) | Histone H2A | polymer | 130 | 14083.4 | 2 | UniProt (Q6AZJ8) | Xenopus laevis (African clawed frog) | |
| 4 | D, H (D, H) | Histone H2B | polymer | 126 | 13939.2 | 2 | UniProt (A0A8J0TWI5) | Xenopus laevis (African clawed frog) | |
| 5 | I (I) | DNA (130-MER) | polymer | 130 | 39924.4 | 1 | Homo sapiens | ||
| 6 | J (J) | DNA (131-MER) | polymer | 131 | 40637.9 | 1 | Homo sapiens | ||
| 7 | K (M) | Polycomb complex protein BMI-1 | polymer | 326 | 37006.1 | 1 | UniProt (P35226) | Homo sapiens (human) | Polycomb group RING finger protein 4,RING finger protein 51 |
| 8 | L (N) | E3 ubiquitin-protein ligase RING2 | polymer | 336 | 37706.4 | 1 | UniProt (Q99496) | Homo sapiens (human) | Huntingtin-interacting protein 2-interacting protein 3,HIP2-interacting protein 3,Protein DinG,RING finger protein 1B,RING1b,RING finger protein 2,RING finger protein BAP-1,RING-type E3 ubiquitin transferase RING2 |
| 9 | M, N, O, P (M, N) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) PubChem (32051) |
Sequence modifications
C, G: 0 - 129 (UniProt: Q6AZJ8)
| PDB | External Database | Details |
|---|---|---|
| Cys 119 | Lys 120 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 264979.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 265240.7 |
