9V6D

Human Ecto-5'-nucleotidase (CD73) in complex with LB10

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	5'-nucleotidase	polymer	529	58913.0	2	UniProt (P21589) Pfam (PF00149) Pfam (PF02872)	Homo sapiens (human)	CD73,5'-NT,5'-deoxynucleotidase,Ecto-5'-nucleotidase,IMP-specific 5'-nucleotidase,Thymidylate 5'-phosphatase
2	C (C)	alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G09724ZC)
3	D (D)	alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G22573RC)
4	E, F (E, F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	G, H (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG) PubChem (24139)
6	I, J, K, N, O... (A, B)	ZINC ION	non-polymer		65.4	6	Chemie (ZN) PubChem (32051)
7	L, Q (A, B)	5-[6-chloranyl-5-(2-phenylethoxy)pyridazin-3-yl]-1~{H}-pyrimidine-2,4-dione	non-polymer		344.8	2	Chemie (A1EQY)
8	M, R (A, B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA) PubChem (271)
9	S, T (A, B)	water	water		18.0	242	Chemie (HOH)

Sequence modifications

A, B: 27 - 549 (UniProt: P21589)

PDB	External Database	Details
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
His 553	-	expression tag
His 554	-	expression tag
His 555	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	117826.0
Branched	Number of molecules	4
	Total formula weight	2670.4
Non-Polymers*	Number of molecules	12
	Total formula weight	1604.5
All*	Total formula weight	122101.0

*Water molecules are not included.