9V5P

Human DNMT1 (aa 698-1616) in complex with hemimethylated dsDNA and inhibitor DMT207

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA (cytosine-5)-methyltransferase 1	polymer	919	103882.1	1	UniProt (P26358)	Homo sapiens (human)	Dnmt1,CXXC-type zinc finger protein 9,DNA methyltransferase HsaI,DNA MTase HsaI,M.HsaI,MCMT
2	B (E)	DNA (5'-D(*CP*CP*TP*TP*CP*CP*GP*TP*AP*AP*GP*T)-3')	polymer	12	3613.4	1		Homo sapiens
3	C (B)	DNA (5'-D(*AP*CP*TP*TP*AP*(5CM)P*GP*GP*AP*AP*GP*G)-3')	polymer	12	3725.5	1		Homo sapiens
4	D, E (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	F (A)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	1	Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
6	G (E)	(2~{R})-2-[3,5-dicyano-1-[2-[2-(dimethylamino)ethyl-methyl-amino]-2-oxidanylidene-ethyl]-4-ethyl-pyrrolo[2,3-b]pyridin-6-yl]sulfanyl-2-(4-methoxyphenyl)ethanamide	non-polymer		533.6	1	Chemie (A1EQ2)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	111221.0
Non-Polymers*	Number of molecules	4
	Total formula weight	1048.9
All*	Total formula weight	112269.9

*Water molecules are not included.