9V2N

Macimorelin bound growth hormone secretagogue receptor in complex with Gq

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Engineered G-alpha-q subunit	polymer	362	41855.6	1		Homo sapiens (human)
2	B (B)	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1	polymer	371	40227.0	1	UniProt (P62873) Pfam (PF00400)	Homo sapiens (human)
3	C (G)	Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	polymer	71	7861.1	1	UniProt (P59768) Pfam (PF00631)	Homo sapiens (human)	G gamma-I
4	D (N)	NB35	polymer	140	15343.0	1		Lama glama
5	E (R)	Soluble cytochrome b562,Growth hormone secretagogue receptor type 1,growth hormone secretagogue receptor	polymer	676	76149.7	1	UniProt (P0ABE7) UniProt (Q92847) Pfam (PF00001)	Escherichia coli	Cytochrome b-562,GHS-R,GH-releasing peptide receptor,GHRP,Ghrelin receptor
6	F (S)	scFv16	polymer	303	32561.3	1		Mus musculus
7	G (R)	Macimorelin	non-polymer		474.6	1	Chemie (A1EQV)

Sequence modifications

B: 2 - 340 (UniProt: P62873)

PDB	External Database	Details
Met -4	-	initiating methionine
Gly -3	-	expression tag
Ser -2	-	expression tag
Leu -1	-	expression tag
Leu 0	-	expression tag
Gln 1	-	expression tag
Gly 341	-	expression tag
Ser 342	-	expression tag
Ser 343	-	expression tag
Gly 344	-	expression tag
Gly 345	-	expression tag
Gly 346	-	expression tag
Gly 347	-	expression tag
Ser 348	-	expression tag
Gly 349	-	expression tag
Gly 350	-	expression tag
Gly 351	-	expression tag
Gly 352	-	expression tag
Ser 353	-	expression tag
Ser 354	-	expression tag
Gly 355	-	expression tag
Val 356	-	expression tag
Ser 357	-	expression tag
Gly 358	-	expression tag
Trp 359	-	expression tag
Arg 360	-	expression tag
Leu 361	-	expression tag
Phe 362	-	expression tag
Lys 363	-	expression tag
Lys 364	-	expression tag
Ile 365	-	expression tag
Ser 366	-	expression tag

R: -105 - 0 (UniProt: P0ABE7)

PDB	External Database	Details
Met -146	-	initiating methionine
Lys -145	-	expression tag
Thr -144	-	expression tag
Ile -143	-	expression tag
Ile -142	-	expression tag
Ala -141	-	expression tag
Leu -140	-	expression tag
Ser -139	-	expression tag
Tyr -138	-	expression tag
Ile -137	-	expression tag
Phe -136	-	expression tag
Cys -135	-	expression tag
Leu -134	-	expression tag
Val -133	-	expression tag
Phe -132	-	expression tag
Ala -131	-	expression tag
His -130	-	expression tag
His -129	-	expression tag
His -128	-	expression tag
His -127	-	expression tag
His -126	-	expression tag
His -125	-	expression tag
His -124	-	expression tag
His -123	-	expression tag
His -122	-	expression tag
His -121	-	expression tag
Pro -120	-	expression tag
Ser -119	-	expression tag
Arg -118	-	expression tag
Leu -117	-	expression tag
Glu -116	-	expression tag
Glu -115	-	expression tag
Glu -114	-	expression tag
Leu -113	-	expression tag
Arg -112	-	expression tag
Arg -111	-	expression tag
Arg -110	-	expression tag
Leu -109	-	expression tag
Thr -108	-	expression tag
Glu -107	-	expression tag
Pro -106	-	expression tag
Trp -99	Met 29	conflict
Ile -4	His 124	conflict
Leu 0	Arg 128	conflict

R: 1 - 366 (UniProt: Q92847)
R: 367 - 529 (PDB: 9V2N)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	213997.7
Non-Polymers*	Number of molecules	1
	Total formula weight	474.6
All*	Total formula weight	214472.3

*Water molecules are not included.